Rede Nordeste de Biotecnologia (RENORBIO), Universidade Federal Rural de Pernambuco (UFRPE), Rua Dom Manuel de Medeiros, Dois Irmãos, Recife CEP 52171-900, Brazil.
Instituto Avançado de Tecnologia e Inovação (IATI), Rua Potyra, n. 31, Prado, Recife CEP 50751-310, Brazil.
Molecules. 2022 Aug 30;27(17):5580. doi: 10.3390/molecules27175580.
Chronic ulcers are among the main causes of morbidity and mortality due to the high probability of infection and sepsis and therefore exert a significant impact on public health resources. Numerous types of dressings are used for the treatment of skin ulcers-each with different advantages and disadvantages. Bacterial cellulose (BC) has received enormous interest in the cosmetic, pharmaceutical, and medical fields due to its biological, physical, and mechanical characteristics, which enable the creation of polymer composites and blends with broad applications. In the medical field, BC was at first used in wound dressings, tissue regeneration, and artificial blood vessels. This material is suitable for treating various skin diseases due its considerable fluid retention and medication loading properties. BC membranes are used as a temporary dressing for skin treatments due to their excellent fit to the body, reduction in pain, and acceleration of epithelial regeneration. BC-based composites and blends have been evaluated and synthesized both in vitro and in vivo to create an ideal microenvironment for wound healing. This review describes different methods of producing and handling BC for use in the medical field and highlights the qualities of BC in detail with emphasis on biomedical reports that demonstrate its utility. Moreover, it gives an account of biomedical applications, especially for tissue engineering and wound dressing materials reported until date. This review also includes patents of BC applied as a wound dressing material.
慢性溃疡是发病率和死亡率的主要原因之一，因为其具有很高的感染和败血症的可能性，因此对公共卫生资源产生了重大影响。有许多类型的敷料用于治疗皮肤溃疡-每种都有不同的优缺点。由于其生物、物理和机械特性，细菌纤维素（BC）在化妆品、制药和医疗领域引起了极大的兴趣，这使其能够创造出具有广泛应用的聚合物复合材料和混合物。在医疗领域，BC 最初用于伤口敷料、组织再生和人造血管。由于其具有相当大的保液性和药物负载特性，这种材料适合治疗各种皮肤病。BC 膜因其与身体的良好贴合性、减轻疼痛和加速上皮再生而被用作皮肤治疗的临时敷料。已经在体外和体内评估和合成了基于 BC 的复合材料和混合物，以创建用于伤口愈合的理想微环境。本综述描述了用于医疗领域的 BC 的不同生产和处理方法，并详细介绍了 BC 的特性，重点介绍了证明其效用的生物医学报告。此外，它还介绍了生物医学应用，特别是迄今为止报道的用于组织工程和伤口敷料材料的应用。本综述还包括 BC 作为伤口敷料材料的专利。
