海绵来源的细胞毒性和抗菌异马烷型三萜

Cytotoxic and Antibacterial Isomalabaricane Terpenoids from the Sponge .

机构信息

Drug Discovery Shandong Laboratory, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, P. R. China.

Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, P. R. China.

出版信息

J Nat Prod. 2022 Jul 22;85(7):1799-1807. doi: 10.1021/acs.jnatprod.2c00348. Epub 2022 Jun 29.

DOI:10.1021/acs.jnatprod.2c00348

PMID:35767002

Abstract

Nine new isomalabaricane terpenoids (-) were isolated from the sponge of Ximao Island, together with 13 known ones (-). The structures were established by spectroscopic data interpretation and chemical calculations, as well as by comparison with spectroscopic data of known compounds. Notably, of the new isolates, hainanstelletin A () is the first representative of a nitrogenous isomalabaricane. The isolated compounds were evaluated against several cancer cell lines and two bacterial pathogens. In addition, moderate to strong antibacterial activities against were also detected among geometric isomers , , and -, with minimum inhibitory concentrations of 0.1-1.8 μg/mL.

摘要

从西沙群岛的海绵中分离得到 9 种新的异马烷萜类化合物（-），并与 13 种已知化合物（-）一起分离得到。通过光谱数据分析和化学计算以及与已知化合物的光谱数据比较，确定了这些化合物的结构。值得注意的是，新分离得到的化合物 hainanstelletin A（-）是第一个含氮异马烷。对分离得到的化合物进行了多种癌细胞系和两种细菌病原体的活性评价。此外，几何异构体、、和 - 也具有中等至较强的抗细菌活性，最小抑菌浓度为 0.1-1.8 μg/mL。