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光学相干断层扫描中基于深度学习的数字重新聚焦。

Digital refocusing based on deep learning in optical coherence tomography.

作者信息

Yuan Zhuoqun, Yang Di, Yang Zihan, Zhao Jingzhu, Liang Yanmei

机构信息

Institute of Modern Optics, Nankai University, Tianjin Key Laboratory of Micro-scale Optical Information Science and Technology, Tianjin 300350, China.

Contributed equally.

出版信息

Biomed Opt Express. 2022 Apr 25;13(5):3005-3020. doi: 10.1364/BOE.453326. eCollection 2022 May 1.

Abstract

We present a deep learning-based digital refocusing approach to extend depth of focus for optical coherence tomography (OCT) in this paper. We built pixel-level registered pairs of low-resolution (LR) and high-resolution (HR) OCT images based on experimental data and introduced the receptive field block into the generative adversarial networks to learn the complex mapping relationship between LR-HR image pairs. It was demonstrated by results of phantom and biological samples that the lateral resolutions of OCT images were improved in a large imaging depth clearly. We firmly believe deep learning methods have broad prospects in optimizing OCT imaging.

摘要

在本文中,我们提出了一种基于深度学习的数字重聚焦方法,以扩展光学相干断层扫描(OCT)的焦深。我们基于实验数据构建了低分辨率(LR)和高分辨率(HR)OCT图像的像素级配准对,并将感受野模块引入生成对抗网络,以学习LR-HR图像对之间的复杂映射关系。体模和生物样本的结果表明,OCT图像的横向分辨率在较大成像深度上得到了显著提高。我们坚信深度学习方法在优化OCT成像方面具有广阔的前景。

相似文献

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Digital refocusing based on deep learning in optical coherence tomography.光学相干断层扫描中基于深度学习的数字重新聚焦。
Biomed Opt Express. 2022 Apr 25;13(5):3005-3020. doi: 10.1364/BOE.453326. eCollection 2022 May 1.

本文引用的文献

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Nat Methods. 2021 Apr;18(4):406-416. doi: 10.1038/s41592-021-01080-z. Epub 2021 Mar 8.
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Deep learning extended depth-of-field microscope for fast and slide-free histology.深度学习扩展景深显微镜,用于快速无载玻片组织学。
Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33051-33060. doi: 10.1073/pnas.2013571117. Epub 2020 Dec 14.
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NanoJ: a high-performance open-source super-resolution microscopy toolbox.NanoJ:一个高性能的开源超分辨率显微镜工具箱。
J Phys D Appl Phys. 2019 Apr 17;52(16):163001. doi: 10.1088/1361-6463/ab0261. Epub 2019 Feb 18.

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