Keita Kadiatou, Darkoh Charles, Okafor Florence
Biological & Environmental Sciences, Alabama Agricultural & Mechanical University, Normal, AL 35762 USA.
Department of Epidemiology, School of Public Health, Center for Infectious Diseases, Human Genetics, and Environmental Sciences, University of Texas Health Science Center, Houston, TX 77030 USA.
SN Appl Sci. 2022;4(8):209. doi: 10.1007/s42452-022-05084-y. Epub 2022 Jul 8.
Antibiotic resistance is a major public health threat of the twenty-first century and represents an important risk to the global economy. Healthcare-associated infections mainly caused by drug-resistant bacteria are wreaking havoc in patient care worldwide. The spread of such pathogens limits the utility of available drugs and complicates the treatment of bacterial diseases. As a result, there is an urgent need for new drugs with mechanisms of action capable of curbing resistance. Plants synthesize and utilize various metabolic compounds to deter pathogens and predators. Utilizing these plant-based metabolites is a promising option in identifying novel bioactive compounds that could be harnessed to develop new potent antimicrobial drugs to treat multidrug-resistant pathogens. The purpose of this review is to highlight medicinal plants as important sources of novel antimicrobial agents that could be developed to help combat antimicrobial resistance.
抗生素耐药性是21世纪主要的公共卫生威胁，对全球经济构成重大风险。主要由耐药细菌引起的医疗保健相关感染正在全球范围内对患者护理造成严重破坏。此类病原体的传播限制了现有药物的效用，并使细菌性疾病的治疗复杂化。因此，迫切需要具有能够抑制耐药性作用机制的新药。植物合成并利用各种代谢化合物来抵御病原体和捕食者。利用这些基于植物的代谢物是识别新型生物活性化合物的一个有前景的选择，这些化合物可用于开发新的强效抗菌药物来治疗多重耐药病原体。本综述的目的是强调药用植物作为新型抗菌剂的重要来源，可开发用于帮助对抗抗菌药物耐药性。
