Liu Juan, Tan Yuzhu, Cheng Hao, Zhang Dandan, Feng Wuwen, Peng Cheng
1State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
2Key Laboratory of the Ministry of Education for Standardization of Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Aging Dis. 2022 Jul 11;13(4):1106-1126. doi: 10.14336/AD.2022.0104.
Gut microbiota, a collection of microorganisms that live within gastrointestinal tract, provides crucial signaling metabolites for the physiological of hosts. In healthy state, gut microbiota metabolites are helpful for maintaining the basic functions of hosts, whereas disturbed production of these metabolites can lead to numerous diseases such as metabolic diseases, cardiovascular diseases, gastrointestinal diseases, neurodegenerative diseases, and cancer. Although there are many reviews about the specific mechanisms of gut microbiota metabolites on specific diseases, there is no comprehensive summarization of the functions of these metabolites. In this Opinion, we discuss the knowledge of gut microbiota metabolites including the types of gut microbiota metabolites and their ways acting on targets. In addition, we summarize their physiological and pathologic functions in health and diseases, such as shaping the composition of gut microbiota and acting as nutrition. This paper can be helpful for understanding the roles of gut microbiota metabolites and thus provide guidance for developing suitable therapeutic strategies to combat microbial-driven diseases and improve health.
肠道微生物群是生活在胃肠道内的微生物集合，为宿主的生理活动提供关键的信号代谢物。在健康状态下，肠道微生物群代谢物有助于维持宿主的基本功能，而这些代谢物产生紊乱会导致多种疾病，如代谢性疾病、心血管疾病、胃肠道疾病、神经退行性疾病和癌症。尽管有许多关于肠道微生物群代谢物对特定疾病具体机制的综述，但对这些代谢物的功能尚无全面总结。在本观点文章中，我们讨论了肠道微生物群代谢物的相关知识，包括肠道微生物群代谢物的类型及其作用于靶点的方式。此外，我们总结了它们在健康和疾病中的生理和病理功能，如塑造肠道微生物群的组成和作为营养物质。本文有助于理解肠道微生物群代谢物的作用，从而为制定合适的治疗策略以对抗微生物驱动的疾病和改善健康提供指导。
