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1
Intravenous infusion of the exosomes derived from human umbilical cord mesenchymal stem cells enhance neurological recovery after traumatic brain injury via suppressing the NF-κB pathway.静脉输注源自人脐带间充质干细胞的外泌体，通过抑制NF-κB通路促进创伤性脑损伤后的神经功能恢复。
Open Life Sci. 2022 Mar 17;17(1):189-201. doi: 10.1515/biol-2022-0022. eCollection 2022.
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Mesenchymal Stem Cells: Therapeutic Mechanisms for Stroke.间充质干细胞：治疗中风的机制。
Int J Mol Sci. 2022 Feb 25;23(5):2550. doi: 10.3390/ijms23052550.
3
Dual Effects of Korean Red Ginseng on Astrocytes and Neural Stem Cells in Traumatic Brain Injury: The HO-1-Tom20 Axis as a Putative Target for Mitochondrial Function.高丽红参对创伤性脑损伤中天冬氨酸能神经胶质细胞和神经干细胞的双重作用：HO-1-Tom20 轴作为线粒体功能的潜在靶点。
Cells. 2022 Mar 4;11(5):892. doi: 10.3390/cells11050892.
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Neural stem cell therapy in conjunction with curcumin loaded in niosomal nanoparticles enhanced recovery from traumatic brain injury.神经干细胞治疗联合姜黄素负载于脂囊泡纳米粒增强创伤性脑损伤的恢复。
Sci Rep. 2022 Mar 4;12(1):3572. doi: 10.1038/s41598-022-07367-1.
5
Efficacy of stem cell secretome in the treatment of traumatic brain injury: A systematic review and meta-analysis of preclinical studies.干细胞分泌液治疗创伤性脑损伤的疗效：临床前研究的系统评价和荟萃分析。
Mol Neurobiol. 2022 May;59(5):2894-2909. doi: 10.1007/s12035-022-02759-w. Epub 2022 Mar 1.
6
Early Treatment With a Single Dose of Mesenchymal Stem Cell Derived Extracellular Vesicles Modulates the Brain Transcriptome to Create Neuroprotective Changes in a Porcine Model of Traumatic Brain Injury and Hemorrhagic Shock.早期单次给予间充质干细胞衍生的细胞外囊泡治疗可调节脑转录组，在创伤性脑损伤和失血性休克的猪模型中产生神经保护作用。
Shock. 2022 Feb 1;57(2):281-290. doi: 10.1097/SHK.0000000000001889.
7
Umbilical cord mesenchymal stem cells promote neurological repair after traumatic brain injury through regulating Treg/Th17 balance.脐带间充质干细胞通过调节 Treg/Th17 平衡促进创伤性脑损伤后的神经修复。
Brain Res. 2022 Jan 15;1775:147711. doi: 10.1016/j.brainres.2021.147711. Epub 2021 Nov 15.
8
Ability to regulate immunity of mesenchymal stem cells in the treatment of traumatic brain injury.调节间充质干细胞免疫功能在创伤性脑损伤治疗中的作用。
Neurol Sci. 2022 Mar;43(3):2157-2164. doi: 10.1007/s10072-021-05529-z. Epub 2021 Aug 10.
9
Pre-clinical study of human umbilical cord mesenchymal stem cell transplantation for the treatment of traumatic brain injury: safety evaluation from immunogenic and oncogenic perspectives.人脐带间充质干细胞移植治疗创伤性脑损伤的临床前研究：从免疫原性和致癌性角度进行安全性评估。
Neural Regen Res. 2022 Feb;17(2):354-361. doi: 10.4103/1673-5374.317985.
10
Combined bioscaffold with stem cells and exosomes can improve traumatic brain injury.联合生物支架与干细胞和外泌体可改善创伤性脑损伤。
Stem Cell Rev Rep. 2020 Apr;16(2):323-334. doi: 10.1007/s12015-019-09927-x.

干细胞在创伤性脑损伤修复中的治疗应用。

Therapeutic Application of Stem Cells in the Repair of Traumatic Brain Injury.

作者信息

Adugna Dagnew Getnet, Aragie Hailu, Kibret Anteneh Ayelign, Belay Daniel Gashaneh

机构信息

Department of Human Anatomy, School of Medicine, College of Medicine and Health Science, University of Gondar, Gondar, Amhara Region, Ethiopia.

Department of Epidemiology, Institution of Public Health, College of Medicine and Health Science, University of Gondar, Gondar, Amhara Region, Ethiopia.

出版信息

Stem Cells Cloning. 2022 Jul 13;15:53-61. doi: 10.2147/SCCAA.S369577. eCollection 2022.

DOI:10.2147/SCCAA.S369577
PMID:35859889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9289752/
Abstract

Traumatic brain injury is the main cause of injury-related deaths and disabilities throughout the world, which is characterized by a disruption of the normal physiology of the brain following trauma. It can potentially cause severe complications such as physical, cognitive, and emotional impairment. In addition to understanding traumatic brain injury pathophysiology, this review explains the therapeutic potential of stem cells following brain injury in two pathways: response of endogenous neurogenic cells and transplantation of exogenous stem cell therapy. After traumatic brain injuries, clinical evidence indicated that endogenous neural progenitor cells might play an important role in regenerative medicine to treat brain injury. This is due to an increased neurogenic regeneration ability of these cells following brain injury. Besides, exogenous stem cell transplantation has also accelerated immature neuronal development and increased endogenous cellular proliferation in the damaged brain region. Therefore, a better understanding of the endogenous neural stem cell's regenerative ability and the effect of exogenous stem cells on proliferation and differentiation ability may help researchers to understand how to increase functional recovery and tissue repair following injury.

摘要

创伤性脑损伤是全球与损伤相关的死亡和残疾的主要原因，其特征是创伤后大脑正常生理功能的破坏。它可能会导致严重的并发症，如身体、认知和情感障碍。除了了解创伤性脑损伤的病理生理学外，本综述还从两条途径解释了脑损伤后干细胞的治疗潜力：内源性神经源性细胞的反应和外源性干细胞治疗的移植。创伤性脑损伤后，临床证据表明内源性神经祖细胞可能在治疗脑损伤的再生医学中发挥重要作用。这是因为这些细胞在脑损伤后神经源性再生能力增强。此外，外源性干细胞移植也加速了未成熟神经元的发育，并增加了受损脑区的内源性细胞增殖。因此，更好地了解内源性神经干细胞的再生能力以及外源性干细胞对增殖和分化能力的影响，可能有助于研究人员了解如何在损伤后促进功能恢复和组织修复。