Grosskopf Abigail K, Saouaf Olivia A, Lopez Hernandez Hector, Appel Eric A
Department of Chemical Engineering Stanford University Stanford California USA.
Department of Materials Science and Engineering Stanford University Stanford California USA.
J Polym Sci (2020). 2021 Nov 15;59(22):2854-2866. doi: 10.1002/pol.20210652. Epub 2021 Oct 22.
Polymer-nanoparticle hydrogels are a unique class of self-assembled, shear-thinning, yield-stress fluids that have demonstrated potential utility in many impactful applications. Here, we present a thorough analysis of the gelation and yielding behavior of these materials with respect to the polymer and nanoparticle component stoichiometry. Through comprehensive rheological and diffusion studies, we reveal insights into the structural dynamics of the polymer nanoparticle network that identify that stoichiometry plays a key role in gelation and yielding, ultimately enabling the development of hydrogel formulations with unique shear-thinning and yield-stress behaviors. Access to these materials opens new doors for interesting applications in a variety of fields including tissue engineering, drug delivery, and controlled solution viscosity.
聚合物-纳米颗粒水凝胶是一类独特的自组装、剪切变稀、具有屈服应力的流体，已在许多重要应用中展现出潜在效用。在此，我们针对这些材料的凝胶化和屈服行为，就聚合物和纳米颗粒组分的化学计量进行了全面分析。通过全面的流变学和扩散研究，我们揭示了聚合物-纳米颗粒网络的结构动力学，确定化学计量在凝胶化和屈服过程中起关键作用，最终促成了具有独特剪切变稀和屈服应力行为的水凝胶配方的开发。获得这些材料为组织工程、药物递送和可控溶液粘度等多个领域的有趣应用打开了新大门。
