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章鱼卵色素天然 phenoxazinone 对致病菌和真菌的抑制作用。

Inhibition of Pathogenic Bacteria and Fungi by Natural Phenoxazinone from Octopus Ommochrome Pigments.

机构信息

Laboratorio de Microbiología y Micotoxinas, Departamento de Investigación y Posgrado en Alimentos, Universidad de Sonora, Blvd. Luis Encinas y Rosales S/N, Col. Centro, 83000 Hermosillo, Sonora, Mexico.

Departamento de Investigaciones Científicas y Tecnológicas, Blvd. Luis Encinas y Rosales S/N, Col. Centro, 83000 Hermosillo, Sonora, México.

出版信息

J Microbiol Biotechnol. 2022 Aug 28;32(8):989-1002. doi: 10.4014/jmb.2206.06043. Epub 2022 Jul 21.

DOI:10.4014/jmb.2206.06043
PMID:35909165
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9628961/
Abstract

Cephalopods, in particular octopus (), have the ability to alter their appearance or body pattern by showing a wide range of camouflage by virtue of their chromatophores, which contain nanostructured granules of ommochrome pigments. Recently, the antioxidant and antimicrobial activities of ommochromes have become of great interest; therefore, in this study, the pH-dependent redox effect of the extraction solvent on the antioxidant potential and the structural characterization of the pigments were evaluated. Cell viability was determined by the microdilution method in broth by turbidity, MTT, resazurin, as well as fluorescence microscopy kit assays. A Live/Dead Double Staining Kit and an ROS Kit were used to elucidate the possible inhibitory mechanisms of ommochromes against bacterial and fungal strains. The results obtained revealed that the redox state alters the color changes of the ommochromes and is dependent on the pH in the extraction solvent. Natural phenoxazinone (ommochromes) is moderately toxic to the pathogens , , and , while the species and , and the filamentous fungi , spp. and , were tolerant to these pigments. UV/visible spectral scanning and Fourier- transform infrared spectroscopy (FTIR) suggest the presence of reduced ommatin in methanol/ HCl extract with high intrinsic fluorescence.

摘要

头足类动物，特别是章鱼（），具有通过其包含纳米结构的章鱼素色素颗粒的色素体显示广泛的伪装来改变外观或身体模式的能力。最近，章鱼素的抗氧化和抗菌活性引起了极大的关注；因此，在这项研究中，评估了提取溶剂的 pH 值依赖性氧化还原效应对抗氧化潜力和色素结构特性的影响。通过浊度、MTT、resazurin 以及荧光显微镜试剂盒测定法在肉汤中通过微稀释法测定细胞活力。使用 Live/Dead 双重染色试剂盒和 ROS 试剂盒阐明了章鱼素对细菌和真菌菌株的可能抑制机制。结果表明，氧化还原状态改变了章鱼素的颜色变化，并且取决于提取溶剂中的 pH 值。天然吩嗪酮（章鱼素）对病原体、和有中度毒性，而物种和以及丝状真菌、和，对这些色素具有耐受性。UV/可见光谱扫描和傅里叶变换红外光谱（FTIR）表明甲醇/HCl 提取物中存在具有高本征荧光的还原型 ommin。

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