Mao Guochao, Li Lan, Shan Changyou, Liang Baobao, Ma Li, Zhang Shuqun
Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Breast Surgery, Shaanxi Provincial Cancer Hospital, Xi'an, China.
Front Med (Lausanne). 2022 Jul 14;9:833301. doi: 10.3389/fmed.2022.833301. eCollection 2022.
Hepatocellular carcinoma (HCC) is known to have a poor prognosis. Accumulating evidence indicates that RRM2 plays a critical role in the occurrence and progression of multiple human cancers. However, the knowledge about RRM2 in HCC is still insufficient, and further research is needed. Here, we first analyzed the expression and prognosis of RRM2 using TCGA and GTEx data, and found that RRM2 may play a potential carcinogenic role in HCC. Then, through a series of comprehensive analysis, including expression analysis, correlation analysis or survival analysis, non-coding RNAs (ncRNAs) that regulate RRM2 overexpression were identified. Finally, MIR4435-2HG/CYTOR were observed to be the most promising upstream lncRNAs for the miR-125b-5p/RRM2 axis in HCC. In addition, RRM2 expression was significantly positively related to immune cell infiltration, immune cell biomarker or immune checkpoint expression in HCC. Altogether, the upregulation of RRM2 mediated by ncRNAs correlates with poor prognosis and tumor immune infiltration of HCC.
肝细胞癌（HCC）的预后较差。越来越多的证据表明，RRM2在多种人类癌症的发生和发展中起关键作用。然而，关于RRM2在HCC中的认识仍然不足，需要进一步研究。在此，我们首先使用TCGA和GTEx数据分析了RRM2的表达和预后，发现RRM2可能在HCC中发挥潜在的致癌作用。然后，通过一系列综合分析，包括表达分析、相关性分析或生存分析，鉴定了调节RRM2过表达的非编码RNA（ncRNA）。最后，观察到MIR4435-2HG/CYTOR是HCC中miR-125b-5p/RRM2轴最有前景的上游长链非编码RNA。此外，RRM2表达与HCC中的免疫细胞浸润、免疫细胞生物标志物或免疫检查点表达显著正相关。总之，由ncRNA介导的RRM2上调与HCC的不良预后和肿瘤免疫浸润相关。
