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由非编码RNA介导的RRM1高表达与肝细胞癌的不良预后和肿瘤免疫浸润相关。

High Expression of RRM1 Mediated by ncRNAs Correlates with Poor Prognosis and Tumor Immune Infiltration of Hepatocellular Carcinoma.

作者信息

Mao Guochao, Shan Changyou, Li Weimiao, Liang Baobao, Ma Li, Zhang Shuqun

机构信息

Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710000, People's Republic of China.

出版信息

Int J Gen Med. 2022 Mar 6;15:2607-2620. doi: 10.2147/IJGM.S353362. eCollection 2022.

DOI:10.2147/IJGM.S353362
PMID:35282644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8910518/
Abstract

INTRODUCTION

Hepatocellular carcinoma (HCC) is one of several tumors with poor prognosis and causes a significant social burden. A growing number of studies have shown that RRM1 plays a crucial role in the development and progression of multiple human cancers. However, the specific role and mechanism of RRM1 have not been fully defined in HCC.

METHODS

TCGA and GTEx data were used for the first time to conduct a pan-cancer analysis of RRM1 expression and prognosis, and identified RRM1 as a possible potential oncogene in HCC. At the same time, a combination of analyses (including expression analysis, correlation analysis or survival analysis) identified non-coding RNAs (ncRNAs) that contribute to RRM1 overexpression.

RESULTS

MIR4435-2HG/miR-22-3p and SNHG6/miR-101-3p were identified as the most promising RRM1 upstream ncRNA-related pathways in HCC. In addition, RRM1 levels were significantly and positively correlated with tumor immune cell infiltration, immune cell biomarker or immune checkpoint expression.

CONCLUSION

These results suggest that high expression of RRM1 mediated by ncRNAs is associated with poor prognosis and tumor immune infiltration in HCC.

摘要

引言

肝细胞癌（HCC）是预后较差的几种肿瘤之一，会造成重大社会负担。越来越多的研究表明，RRM1在多种人类癌症的发生和发展中起关键作用。然而，RRM1在HCC中的具体作用和机制尚未完全明确。

方法

首次使用TCGA和GTEx数据对RRM1表达和预后进行泛癌分析，并确定RRM1为HCC中一种可能的潜在癌基因。同时，综合分析（包括表达分析、相关性分析或生存分析）确定了导致RRM1过表达的非编码RNA（ncRNA）。

结果

MIR4435-2HG/miR-22-3p和SNHG6/miR-101-3p被确定为HCC中最有前景的RRM1上游ncRNA相关通路。此外，RRM1水平与肿瘤免疫细胞浸润、免疫细胞生物标志物或免疫检查点表达显著正相关。

结论

这些结果表明，ncRNA介导的RRM1高表达与HCC的不良预后和肿瘤免疫浸润相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23c8/8910518/50ec4e52ca36/IJGM-15-2607-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23c8/8910518/793c16dc5a32/IJGM-15-2607-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23c8/8910518/c590348d7b4e/IJGM-15-2607-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23c8/8910518/4cf172dcdb9d/IJGM-15-2607-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23c8/8910518/cb0d839ef68f/IJGM-15-2607-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23c8/8910518/2ee3ddf21c06/IJGM-15-2607-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23c8/8910518/e182c6f5d4fd/IJGM-15-2607-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23c8/8910518/64b968eadc5e/IJGM-15-2607-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23c8/8910518/50ec4e52ca36/IJGM-15-2607-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23c8/8910518/793c16dc5a32/IJGM-15-2607-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23c8/8910518/c590348d7b4e/IJGM-15-2607-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23c8/8910518/4cf172dcdb9d/IJGM-15-2607-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23c8/8910518/cb0d839ef68f/IJGM-15-2607-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23c8/8910518/2ee3ddf21c06/IJGM-15-2607-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23c8/8910518/e182c6f5d4fd/IJGM-15-2607-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23c8/8910518/64b968eadc5e/IJGM-15-2607-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23c8/8910518/50ec4e52ca36/IJGM-15-2607-g0008.jpg

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