Malik Renuka, Pokeria Chanderkala, Singh Swati
Department of OB-GYN, ABVIMS & DR RML Hospital, New Delhi, India.
J Obstet Gynaecol India. 2022 Aug;72(4):322-329. doi: 10.1007/s13224-021-01518-6. Epub 2021 Jul 12.
Menopause is a hypoestrogenic state. Menopausal symptoms like hot flushes, depression, joint pains and urinary symptoms all correlate with falling estrogen levels.
Four hundred postmenopausal women who underwent natural menopause were included in the study conducted from Nov 2018 to March 2020. Surgical menopause, premature menopause and those on hormone replacement were excluded. Serum estradiol was measured and assessment of severity of menopausal symptoms was done using MRS questionnaire. MRS score of 0-4, 5-8, 9-15 and more than 16 were taken as none/minimal, mild, moderate and severe postmenopausal symptoms, respectively. Correlation between serum estradiol and symptoms was analyzed statistically.
Mean age of menopause in our study population was found to be 47.2 ± 3.96 years. Somatic symptoms were found maximum out of all 3 subscales in study population. Psychological subscale which included depression and mood changes was found to have the strongest correlation with serum estradiol level compared to other two subscales (somatic and genito-urinary).
Psychological symptoms, somatic symptoms and genitor urinary symptoms at menopause show correlation with falling estrogen levels. We found maximum correlation of psychological symptoms with low serum estradiol level.
There is an inverse correlation of serum estradiol value with menopausal symptoms, with psychological symptoms (depression, anxiety, mood changes) showing highest correlation with low estrogen levels.
更年期是一种雌激素水平低下的状态。潮热、抑郁、关节疼痛和泌尿系统症状等更年期症状均与雌激素水平下降相关。
纳入2018年11月至2020年3月期间进行自然绝经的400名绝经后妇女进行研究。排除手术绝经、过早绝经及接受激素替代治疗的妇女。测定血清雌二醇水平，并使用MRS问卷对更年期症状的严重程度进行评估。MRS评分为0 - 4分、5 - 8分、9 - 15分及超过16分分别被视为无/轻微、轻度、中度和重度绝经后症状。对血清雌二醇水平与症状之间的相关性进行统计学分析。
研究人群的平均绝经年龄为47.2±3.96岁。在研究人群的所有3个分量表中，躯体症状最为常见。与其他两个分量表（躯体和生殖泌尿系统）相比，包括抑郁和情绪变化的心理分量表与血清雌二醇水平的相关性最强。
更年期的心理症状、躯体症状和生殖泌尿系统症状与雌激素水平下降相关。我们发现心理症状与低血清雌二醇水平的相关性最高。
血清雌二醇值与更年期症状呈负相关，其中心理症状（抑郁、焦虑、情绪变化）与低雌激素水平的相关性最高。
