Fang Lingling, Wang Xin
Department of Computing and Information Technology, Liaoning Normal University, Dalian City, Liaoning Province, China.
Biocybern Biomed Eng. 2022 Jul-Sep;42(3):977-994. doi: 10.1016/j.bbe.2022.07.009. Epub 2022 Aug 5.
Corona virus disease 2019 (COVID-19) testing relies on traditional screening methods, which require a lot of manpower and material resources. Recently, to effectively reduce the damage caused by radiation and enhance effectiveness, deep learning of classifying COVID-19 negative and positive using the mixed dataset by CT and X-rays images have achieved remarkable research results. However, the details presented on CT and X-ray images have pathological diversity and similarity features, thus increasing the difficulty for physicians to judge specific cases. On this basis, this paper proposes a novel coronavirus pneumonia classification model using the mixed dataset by CT and X-rays images. To solve the problem of feature similarity between lung diseases and COVID-19, the extracted features are enhanced by an adaptive region enhancement algorithm. Besides, the depth network based on the residual blocks and the dense blocks is trained and tested. On the one hand, the residual blocks effectively improve the accuracy of the model and the non-linear COVID-19 features are obtained by cross-layer link. On the other hand, the dense blocks effectively improve the robustness of the model by connecting local and abstract information. On mixed X-ray and CT datasets, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), area under curve (AUC), and accuracy can all reach 0.99. On the basis of respecting patient privacy and ethics, the proposed algorithm using the mixed dataset from real cases can effectively assist doctors in performing the accurate COVID-19 negative and positive classification to determine the infection status of patients.
2019冠状病毒病(COVID-19)检测依赖于传统筛查方法,这需要大量人力和物力。最近,为了有效减少辐射造成的损害并提高有效性,利用CT和X光图像的混合数据集对COVID-19阴性和阳性进行深度学习分类取得了显著的研究成果。然而,CT和X光图像呈现的细节具有病理多样性和相似性特征,从而增加了医生判断具体病例的难度。在此基础上,本文提出了一种利用CT和X光图像的混合数据集的新型冠状病毒肺炎分类模型。为了解决肺部疾病与COVID-19之间特征相似的问题,通过自适应区域增强算法对提取的特征进行增强。此外,对基于残差块和密集块的深度网络进行了训练和测试。一方面,残差块有效地提高了模型的准确率,并通过跨层链接获得了非线性的COVID-19特征。另一方面,密集块通过连接局部和抽象信息有效地提高了模型的鲁棒性。在混合X光和CT数据集上,灵敏度、特异性、阳性预测值(PPV)、阴性预测值(NPV)、曲线下面积(AUC)和准确率均可达0.99。在尊重患者隐私和伦理的基础上,所提出的使用真实病例混合数据集的算法能够有效地协助医生对COVID-19进行准确的阴性和阳性分类,以确定患者的感染状况。