Oldenburg B, Diepersloot R J, Hoekstra J B
Department of Internal Medicine, Diakonessen Hospital, Utrecht, The Netherlands.
Dig Dis Sci. 1996 Mar;41(3):458-61. doi: 10.1007/BF02282318.
To assess the prevalence of Helicobacter pylori in diabetes mellitus, a serological test used to detect antibodies to H. Pylori in patients with diabetes mellitus. Within six months, 45 insulin-dependent, 98 non-insulin-dependent, and a control group of 159 outpatients were enrolled in this study. The age adjusted seroprevalence rate of Helicobacter pylori were determined using a commercial anti-Helicobacter pylori IgC and IgA ELISA (Bio-Rad). The prevalence rates increased with age in all age groups until 60-70 years. In diabetic patients, the frequency of Helicobacter pylori infection was higher than control subjects in nearly all age groups, reaching significance in three age categories of NIDDM patients and in one age category in IDDM patients. This higher seroprevalence could not be explained by differences in socioeconomic status or use of antibiotics.
为评估糖尿病患者中幽门螺杆菌的感染率，采用血清学检测方法检测糖尿病患者体内抗幽门螺杆菌抗体。在六个月内，本研究纳入了45例胰岛素依赖型患者、98例非胰岛素依赖型患者以及159例门诊对照组患者。使用商用抗幽门螺杆菌IgC和IgA酶联免疫吸附测定法（伯乐公司）测定幽门螺杆菌的年龄校正血清流行率。在所有年龄组中，直至60 - 70岁，流行率均随年龄增长而升高。在糖尿病患者中，几乎所有年龄组的幽门螺杆菌感染频率均高于对照组，在非胰岛素依赖型糖尿病患者的三个年龄类别以及胰岛素依赖型糖尿病患者的一个年龄类别中达到显著水平。这种较高的血清流行率无法用社会经济地位或抗生素使用差异来解释。
