Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Pharmacy Department, Xiangtan Central Hospital, Xiangtan 411100, China.
Cells. 2022 Aug 16;11(16):2529. doi: 10.3390/cells11162529.
Neurological diseases, including Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), stroke, cerebral infarction, ischemia-reperfusion injury, depression and, stress, have high incidence and morbidity and often lead to disability. However, there is no particularly effective medication against them. Therefore, finding drugs with a suitable efficacy, low toxicity and manageable effects to improve the quality of life of patients is an urgent problem. Ginsenoside Rg1 (Rg1) is the main active component of ginseng and has a variety of pharmacological effects. In this review, we focused on the therapeutic potential of Rg1 for improving neurological diseases. We introduce the mechanisms of Ginsenoside Rg1 in neurological diseases, including apoptosis, neuroinflammation, the microRNA (miRNA) family, the mitogen-activated protein kinase (MAPK) family, oxidative stress, nuclear factor-κB (NF-κB), and learning and memory of Rg1 in neurological diseases. In addition, Rg1 can also improve neurological diseases through the interaction of different signal pathways. The purpose of this review is to explore more in-depth ideas for the clinical treatment of neurological diseases (including PD, AD, HD, stroke, cerebral infarction, ischemia-reperfusion injury, depression, and stress). Therefore, Rg1 is expected to become a new therapeutic method for the clinical treatment of neurological diseases.
神经系统疾病，包括帕金森病（PD）、阿尔茨海默病（AD）、亨廷顿病（HD）、中风、脑梗死、缺血再灌注损伤、抑郁和应激，具有较高的发病率和患病率，常导致残疾。然而，目前针对这些疾病并没有特别有效的药物。因此，寻找疗效适宜、毒性低、作用可调控的药物，以提高患者的生活质量，是一个亟待解决的问题。人参皂苷 Rg1（Rg1）是人参的主要活性成分，具有多种药理作用。在这篇综述中，我们重点介绍了 Rg1 改善神经系统疾病的治疗潜力。我们介绍了 Ginsenoside Rg1 在神经系统疾病中的作用机制，包括凋亡、神经炎症、微小 RNA（miRNA）家族、丝裂原活化蛋白激酶（MAPK）家族、氧化应激、核因子-κB（NF-κB）和 Rg1 对学习和记忆的影响。此外，Rg1 还可以通过不同信号通路的相互作用来改善神经系统疾病。本文的目的是探讨更多关于神经系统疾病（包括 PD、AD、HD、中风、脑梗死、缺血再灌注损伤、抑郁和应激）临床治疗的深入思路。因此，Rg1 有望成为治疗神经系统疾病的新方法。
