Vijay Asha Srinivasan, Gopireddy Murali Mohan Reddy, Fyzullah Syed, Gollapalli Priyanka, Maheswari M, Rani Usha, Rajesh Swathi
Scientific Director and Dean, GarbhaGudi Institute of Reproductive Health and Research (GGIRHR), Hanumanthnagar, Bangalore, India.
Evidence Generation, Evidencian Research Associates, Bangalore, India.
J Reprod Infertil. 2022 Jan-Mar;23(1):54-60. doi: 10.18502/jri.v23i1.8453.
Anti-mullerian hormone (AMH) is a marker for predicting ovarian response to gonadotropin stimulation. It plays an important role in ovarian primordial follicle recruitment and dominant follicle selection. Therefore, the present study evaluated the AMH levels and their association with fertility/reproductive outcomes among women undergoing IVF.
A retrospective study was conducted on 665 women in GarbhaGudi Institute of Reproductive Health and Research in India from October 2018 to 2019. Subjects were divided into ≥1.1 and ≤1.1 AMH level groups. Data on age, luteinizing hormone; LH (), follicle-stimulating hormone values; FSH (), LH value, oocytes retrieved, and oocytes fertilization were collected. AMH category was considered as the primary explanatory variable. Independent sample t-test and chi-square tests were performed. The p<0.05 was considered statistically significant.
Couple's age, FSH values (), number of large follicles, matured oocytes, fertilized oocytes, and cleaved embryos were statistically significant (p<0.001) among subjects with ≥1.1 AMH values. Percentage of women with successful embryo transfer was slightly higher among AMH category 1.1 (p=0.09). Fertilization rate (86.67±20.08 . 83.64±21.39, p=0.18) and clinical pregnancy rate (43.38% . 36.36%, p=0.19) were slightly higher among women with AMH level of ≥1.1 as compared to AMH of <1.1. Live birth rate was slightly higher among women with AMH level of 1.1 (25.85% . 22.22%, p=0.45). Also, the number of fertilized oocytes was associated with clinical pregnancy rate (aOR=1.20, 95%CI 1.09-1.33).
Women with ≥1.10 serum AMH levels had more number of retrieved oocytes, good oocyte quality, increased embryo transfer, and fertilization rates.
抗苗勒管激素（AMH）是预测卵巢对促性腺激素刺激反应的标志物。它在卵巢原始卵泡募集和优势卵泡选择中起重要作用。因此，本研究评估了接受体外受精（IVF）的女性的AMH水平及其与生育力/生殖结局的关联。
对2018年10月至2019年在印度GarbhaGudi生殖健康与研究所的665名女性进行了一项回顾性研究。受试者被分为AMH水平≥1.1和≤1.1两组。收集了年龄、促黄体生成素（LH）值、促卵泡生成素（FSH）值、LH值、取卵数和卵母细胞受精情况的数据。AMH类别被视为主要解释变量。进行了独立样本t检验和卡方检验。p<0.05被认为具有统计学意义。
在AMH值≥1.1的受试者中，夫妻年龄、FSH值、大卵泡数量、成熟卵母细胞、受精卵母细胞和分裂胚胎数量具有统计学意义（p<0.001）。在AMH类别为1.1的女性中，成功胚胎移植的女性百分比略高（p=0.09）。与AMH<1.1的女性相比，AMH水平≥1.1的女性的受精率（86.67±20.08对83.64±21.39，p=0.18）和临床妊娠率（43.38%对36.36%，p=0.19）略高。AMH水平为1.1的女性的活产率略高（25.85%对22.22%，p=0.45）。此外，受精卵母细胞数量与临床妊娠率相关（调整后比值比[aOR]=1.20，95%置信区间[CI]1.09-1.33）。
血清AMH水平≥1.10的女性取卵数更多、卵母细胞质量良好、胚胎移植和受精率增加。
