Stone-Dorshow T, Levitt M D
Am J Clin Nutr. 1987 Jul;46(1):61-5. doi: 10.1093/ajcn/46.1.61.
Fructo-oligosaccharides are naturally occurring sweet substances that are poorly absorbed and have the potential to be clinically useful nonnutritive sweeteners. Because most nonabsorbed carbohydrates are fermented yielding gas, we assessed flatulent symptoms and H2 excretion during ingestion of fructo-oligosaccharide (5 g tid) for 12 d. Ten subjects had significantly greater flatulence while taking the oligosaccharide than did five subjects taking sucrose (5 g tid). Breath H2 after 10 g fructo-oligosaccharide was similar to that of 10 g lactulose, suggesting near total malabsorption of the fructo-oligosaccharide. Although previous studies found a marked diminution in breath H2 after prolonged exposure to lactulose, breath H2 response increased by 50% after a 12-d period on the oligosaccharide and gaseous symptoms did not improve. We conclude that adaptation of colonic bacteria to carbohydrate malabsorption is variable and may depend upon quantity or nature of the carbohydrate.
低聚果糖是天然存在的甜味物质，吸收性差，有潜力成为临床上有用的非营养性甜味剂。由于大多数未被吸收的碳水化合物会发酵产生气体，我们评估了12天内摄入低聚果糖（5克，每日三次）期间的肠胃胀气症状和氢气排泄情况。10名受试者在服用低聚果糖时的肠胃胀气明显比5名服用蔗糖（5克，每日三次）的受试者更严重。10克低聚果糖后的呼气氢气量与10克乳果糖后的相似，表明低聚果糖几乎完全吸收不良。尽管先前的研究发现长期接触乳果糖后呼气氢气量显著减少，但在服用低聚果糖12天后，呼气氢气反应增加了50%，且气体症状并未改善。我们得出结论，结肠细菌对碳水化合物吸收不良的适应性是可变的，可能取决于碳水化合物的数量或性质。
