二氧化硅纳米颗粒的毒理学概况。
A toxicological profile of silica nanoparticles.
作者信息
Liu James Y, Sayes Christie M
机构信息
Department of Environmental Science, Baylor University, One Bear Place # 97266, Waco, TX 76798-7266, United States.
出版信息
Toxicol Res (Camb). 2022 Jul 16;11(4):565-582. doi: 10.1093/toxres/tfac038. eCollection 2022 Aug.
Abstract
Humans are regularly exposed to silica nanoparticles in environmental and occupational contexts, and these exposures have been implicated in the onset of adverse health effects. Existing reviews on silica nanoparticle toxicity are few and not comprehensive. There are natural and synthetic sources by which crystalline and amorphous silica nanoparticles are produced. These processes influence physiochemical properties, which are factors that can dictate toxicological effects. Toxicological assessment includes exposure scenario (e.g. environmental, occupational), route of exposure, toxicokinetics, and toxicodynamics. Broader considerations include pathology, risk assessment, regulation, and treatment after injury. This review aims to consolidate the most relevant and up-to-date research in these areas to provide an exhaustive toxicological profile of silica nanoparticles.
摘要
在环境和职业环境中，人类经常接触二氧化硅纳米颗粒，这些接触与不良健康影响的发生有关。现有的关于二氧化硅纳米颗粒毒性的综述很少且不全面。有天然和合成来源可产生结晶和无定形二氧化硅纳米颗粒。这些过程会影响物理化学性质，而物理化学性质是决定毒理学效应的因素。毒理学评估包括暴露情况（如环境、职业）、暴露途径、毒代动力学和毒效动力学。更广泛的考虑因素包括病理学、风险评估、监管以及损伤后的治疗。本综述旨在整合这些领域中最相关和最新的研究，以提供二氧化硅纳米颗粒详尽的毒理学概况。
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