Coxa Hospital for Joint Replacement, Tampere, Finland.
Faculty of Medicine and Health Technology, University of Tampere, Tampere, Finland.
PLoS One. 2022 Sep 9;17(9):e0274384. doi: 10.1371/journal.pone.0274384. eCollection 2022.
Dislocation is one of the most common complications after primary total hip arthroplasty (THA). Several patient-related risk factors for dislocation have been reported in the previous literature, but only few prediction models for dislocation have been made. Our aim was to build a prediction model for an early (within the first 2 years) revision for dislocation after primary THA using two different statistical methods. The study data constituted of 37 pre- or perioperative variables and postoperative follow-up data of 16 454 primary THAs performed at our institution in 2008-2021. Model I was a traditional logistic regression model and Model II was based on the elastic net method that utilizes machine learning. The models' overall performance was measured using the pseudo R2 values. The discrimination of the models was measured using C-index in Model I and Area Under the Curve (AUC) in Model II. Calibration curves were made for both models. At 2 years postoperatively, 95 hips (0.6% prevalence) had been revised for dislocation. The pseudo R2 values were 0.04 in Model I and 0.02 in Model II indicating low predictive capability in both models. The C-index in Model I was 0.67 and the AUC in Model II was 0.73 indicating modest discrimination. The prediction of an early revision for dislocation after primary THA is difficult even in a large cohort of patients with detailed data available because of the reasonably low prevalence and multifactorial nature of dislocation. Therefore, the risk of dislocation should be kept in mind in every primary THA, whether the patient has predisposing factors for dislocation or not. Further, when conducting a prediction model, sophisticated methods that utilize machine learning may not necessarily offer significant advantage over traditional statistical methods in clinical setup.
脱位是初次全髋关节置换术(THA)后最常见的并发症之一。既往文献报道了多种与患者相关的脱位危险因素,但仅有少数脱位预测模型。我们的目的是使用两种不同的统计方法建立初次 THA 后早期(2 年内)因脱位而翻修的预测模型。该研究的数据包括 2008 年至 2021 年在我院进行的 16454 例初次 THA 的术前或围手术期变量和术后随访数据。模型 I 是传统的逻辑回归模型,模型 II 基于弹性网络方法,利用机器学习。模型的整体性能通过伪 R2 值进行测量。模型 I 的判别能力通过 C 指数进行测量,模型 II 的判别能力通过曲线下面积(AUC)进行测量。为两个模型都制作了校准曲线。术后 2 年,95 髋(0.6%的患病率)因脱位而翻修。模型 I 的伪 R2 值为 0.04,模型 II 的伪 R2 值为 0.02,表明两个模型的预测能力都较低。模型 I 的 C 指数为 0.67,模型 II 的 AUC 为 0.73,表明有一定的判别能力。即使在具有详细数据的大量患者中,由于脱位的合理低患病率和多因素性质,初次 THA 后早期翻修脱位的预测也很困难。因此,无论患者是否存在脱位的易患因素,在进行初次 THA 时都应牢记脱位的风险。此外,在进行预测模型时,利用机器学习的复杂方法在临床设置中不一定比传统统计方法具有显著优势。