De Marchi Thiago, Ferlito João Vitor, Ferlito Marcos Vinicius, Salvador Mirian, Leal-Junior Ernesto Cesar Pinto
Laboratory of Phototherapy and Innovative Technologies in Health (LaPIT), Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho (UNINOVE), São Paulo 03155-000, Brazil.
Postgraduate Program in Biotechnology, Oxidative Stress and Antioxidant Laboratory, University of Caxias do Sul, Caxias do Sul 95070-560, Brazil.
Antioxidants (Basel). 2022 Aug 27;11(9):1671. doi: 10.3390/antiox11091671.
Oxidative stress induced by exercise has been a research field in constant growth, due to its relationship with the processes of fatigue, decreased production of muscle strength, and its ability to cause damage to the cell. In this context, photobiomodulation therapy (PBMT) has emerged as a resource capable of improving performance, while reducing muscle fatigue and muscle damage. To analyze the effects of PBMT about exercise-induced oxidative stress and compare with placebo therapy.
Databases such as PubMed, EMBASE, CINAHL, CENTRAL, PeDro, and Virtual Health Library, which include Lilacs, Medline, and SciELO, were searched to find published studies.
There was no year or language restriction; randomized clinical trials with healthy subjects that compared the application (before or after exercise) of PBMT to placebo therapy were included.
Systematic review with meta-analysis.
Data on the characteristics of the volunteers, study design, intervention parameters, exercise protocol and oxidative stress biomarkers were extracted. The risk of bias and the certainty of the evidence were assessed using the PEDro scale and the GRADE system, respectively.
Eight studies (n = 140 participants) were eligible for this review, with moderate to excellent methodological quality. In particular, PBMT was able to reduce damage to lipids post exercise (SMD = -0.72, CI 95% -1.42 to -0.02, I = 77%, = 0.04) and proteins (SMD = -0.41, CI 95% -0.65 to -0.16, I = 0%, = 0.001) until 72 h and 96 h, respectively. In addition, it increased the activity of SOD enzymes (SMD = 0.54, CI 95% 0.07 to 1.02, I = 42%, = 0.02) post exercise, 48 and 96 h after irradiation. However, PBMT did not increase CAT activity (MD = 0.18 CI 95% -0.56 to 0.91, I = 79%, = 0.64) post exercise. We did not find any difference in TAC or GPx biomarkers.
Low to moderate certainty evidence shows that PBMT is a resource that can reduce oxidative damage and increase enzymatic antioxidant activity post exercise. We found evidence to support that one session of PBMT can modulate the redox metabolism.
运动诱导的氧化应激一直是一个不断发展的研究领域，因为它与疲劳过程、肌肉力量产生减少以及对细胞造成损伤的能力有关。在此背景下，光生物调节疗法（PBMT）已成为一种能够提高运动表现、同时减少肌肉疲劳和肌肉损伤的方法。分析PBMT对运动诱导的氧化应激的影响，并与安慰剂疗法进行比较。
检索了PubMed、EMBASE、CINAHL、CENTRAL、PeDro和虚拟健康图书馆等数据库，其中包括Lilacs、Medline和SciELO，以查找已发表的研究。
无年份或语言限制；纳入了对健康受试者进行的随机临床试验，这些试验比较了PBMT（运动前或运动后）与安慰剂疗法的应用情况。
系统评价并进行荟萃分析。
提取了关于志愿者特征、研究设计、干预参数、运动方案和氧化应激生物标志物的数据。分别使用PEDro量表和GRADE系统评估偏倚风险和证据的确定性。
八项研究（n = 140名参与者）符合本综述的要求，方法学质量为中等至优秀。特别是，PBMT能够分别在运动后72小时和96小时减少脂质损伤（标准化均数差[SMD]= -0.72，95%置信区间[-1.42至-0.02]，I² = 77%，P = 0.04）和蛋白质损伤（SMD = -0.41，95%置信区间[-0.65至-0.16]，I² = 0%，P = 0.001）。此外，在照射后运动后48小时和96小时，它增加了超氧化物歧化酶（SOD）的活性（SMD = 0.54，95%置信区间[0.07至1.02]，I² = 42%，P = 0.02）。然而，PBMT在运动后并未增加过氧化氢酶（CAT）的活性（平均差[MD]= 0.18，95%置信区间[-0.56至0.91]，I² = 79%，P = 0.64）。我们在总抗氧化能力（TAC）或谷胱甘肽过氧化物酶（GPx）生物标志物方面未发现任何差异。
低至中等确定性的证据表明，PBMT是一种可以减少运动后氧化损伤并增加酶促抗氧化活性的方法。我们发现有证据支持一次PBMT治疗可以调节氧化还原代谢。
