A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Palchevskogo Str. 17, 690041 Vladivostok, Russia.
Nutrients. 2022 Sep 19;14(18):3879. doi: 10.3390/nu14183879.
Neuroinflammation plays a critical role in the pathogenesis of most neurological and neurodegenerative diseases and therefore represents a potential therapeutic target. In this regard, accelerating the resolution process in chronic neuroinflammation may be an effective strategy to deal with the cognitive consequences of neuropathology and generalized inflammatory processes. -acylethanolamine (NAE) derivatives of fatty acids, being highly active lipid mediators, possess pro-resolving activity in inflammatory processes and are promising agents for the suppression of neuroinflammation and its consequences. This paper is devoted to a study of the effects played by dietary supplement (DS), containing a composition of fatty acid-derived NAEs, obtained from squid , on the hippocampal neuroinflammatory and memory processes. By detecting the production of pro-inflammatory cytokines and glial markers, a pronounced anti-inflammatory activity of DS was demonstrated both in vitro and in vivo. DS administration reversed the LPS-induced reduction in hippocampal neurogenesis and memory deterioration. LC-MS analysis revealed an increase in the production of a range of NAEs with well-documented anti-inflammatory activity in response to the administered lipid composition. To conclude, we found that tested DS suppresses the neuroinflammatory response by reducing glial activation, positively regulates neural progenitor proliferation, and attenuates hippocampal-dependent memory impairment.
神经炎症在大多数神经和神经退行性疾病的发病机制中起着关键作用，因此代表了一个潜在的治疗靶点。在这方面，加速慢性神经炎症的消退过程可能是应对神经病理学和全身性炎症过程的认知后果的有效策略。酰基乙醇胺 (NAE) 衍生物是高度活跃的脂质介质，在炎症过程中具有促消退活性，是抑制神经炎症及其后果的有前途的药物。本文致力于研究膳食补充剂 (DS) 的作用，该补充剂含有鱿鱼衍生脂肪酸的 NAE 成分，对海马神经炎症和记忆过程的影响。通过检测促炎细胞因子和神经胶质标志物的产生，证明 DS 具有明显的抗炎活性，无论是在体外还是体内。DS 给药逆转了 LPS 诱导的海马神经发生减少和记忆恶化。LC-MS 分析显示，在响应所给予的脂质组成时，产生了一系列具有明确抗炎活性的 NAE 的产量增加。总之，我们发现测试的 DS 通过减少神经胶质细胞激活来抑制神经炎症反应，积极调节神经祖细胞增殖，并减轻海马依赖性记忆损伤。
