Arch Marta, Vidal Maria, Koiffman Romina, Melkie Solomon Tibebu, Cardona Pere-Joan
Tuberculosis Research Unit, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.
Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Front Microbiol. 2022 Oct 20;13:991678. doi: 10.3389/fmicb.2022.991678. eCollection 2022.
Over the last decades, research regarding innate immune responses has gained increasing importance. A growing body of evidence supports the notion that the innate arm of the immune system could show memory traits. Such traits are thought to be conserved throughout evolution and provide a survival advantage. Several models are available to study these mechanisms. Among them, we find the fruit fly, . This non-mammalian model has been widely used for innate immune research since it naturally lacks an adaptive response. Here, we aim to review the latest advances in the study of the memory mechanisms of the innate immune response using this animal model.
在过去几十年中，关于先天性免疫反应的研究变得越来越重要。越来越多的证据支持这样一种观点，即免疫系统的先天性分支可能表现出记忆特性。这些特性被认为在整个进化过程中是保守的，并提供生存优势。有几种模型可用于研究这些机制。其中，我们发现了果蝇。这种非哺乳动物模型由于自然缺乏适应性反应，已被广泛用于先天性免疫研究。在这里，我们旨在综述使用这种动物模型研究先天性免疫反应记忆机制的最新进展。
