CMB-HUNT: Automatic detection of cerebral microbleeds using a deep neural network.

Cerebral microbleeds (CMBs) are gaining increasing interest due to their importance in diagnosing cerebral small vessel diseases. However, manual inspection of CMBs is time-consuming and prone to human error. Existing automated or semi-automated solutions still have insufficient detection sensitivity and specificity. Furthermore, they frequently use more than one magnetic resonance imaging modality, but these are not always available. The majority of AI-based solutions use either numeric or image data, which may not provide sufficient information about the true nature of CMBs. This paper proposes a deep neural network with multi-type input data for automated CMB detection (CMB-HUNT) using only susceptibility-weighted imaging data (SWI). Combination of SWIs and radiomic-type numerical features allowed us to identify CMBs with high accuracy without the need for additional imaging modalities or complex predictive models. Two independent datasets were used: one with 304 patients (39 with CMBs) for training and internal system validation and one with 61 patients (21 with CMBs) for external validation. For the hold-out testing dataset, CMB-HUNT reached a sensitivity of 90.0%. As results of testing showed, CMB-HUNT outperforms existing methods in terms of the number of FPs per case, which is the lowest reported thus far (0.54 FPs/patient). The proposed system was successfully applied to the independent validation set, reaching a sensitivity of 91.5% with 1.9 false positives per patient and proving its generalization potential. The results were comparable to previous studies. Our research confirms the usefulness of deep learning solutions for CMB detection based only on one MRI modality.