认知功能障碍与25项国立眼科研究所视觉功能问卷
Cognitive dysfunction and the 25-item National Eye Institute Visual Function Questionnaire.
作者信息
Mozdbar Sima, Alber Jessica, Aryal Subhash, Johnson Leigh, Moroz Alina, Rashik Mohammad, Mostafavi Amir, O'Bryant Sid
机构信息
Department of Pharmacology & Neuroscience North Texas Eye Research Institute University of North Texas Health Science Center Fort Worth Texas USA.
TCU and UNTHSC School of Medicine Fort Worth Texas USA.
出版信息
Alzheimers Dement (Amst). 2022 Nov 15;14(1):e12378. doi: 10.1002/dad2.12378. eCollection 2022.
INTRODUCTION
Visual function and cognitive impairment are interrelated; however, little is known about the impact of modifying treatable vision impairment on the development of cognitive dysfunction. This study examines the relationship between cognition and self-reported visual function using the National Eye Institute's Visual Function Questionnaire (NEI VFQ).
METHODS
Participants completed the NEI VFQ 25-Item questionnaire as well as the Mini-Mental State Examination (MMSE). Additionally, all participants were assigned a consensus clinical diagnosis based on established criteria. We used a general linear model and analysis of variance approach to compare means between multiple groups.
RESULTS
A significant association between overall composite score on the NEI VFQ and total MMSE score was revealed ( = 0.04). On average, for every 1-point increase in MMSE score, the overall composite score increased by 0.40 units (95% confidence interval: 0.03-0.77).
DISCUSSION
Reduced visual function should raise concerns about cognitive decline and prompt additional assessment.
引言
视觉功能与认知障碍相互关联；然而，关于改善可治疗的视力障碍对认知功能障碍发展的影响，我们所知甚少。本研究使用美国国立眼科研究所视觉功能问卷（NEI VFQ）来检验认知与自我报告的视觉功能之间的关系。
方法
参与者完成了NEI VFQ 25项问卷以及简易精神状态检查表（MMSE）。此外，根据既定标准为所有参与者进行了共识临床诊断。我们使用一般线性模型和方差分析方法来比较多组之间的均值。
结果
NEI VFQ的总体综合得分与MMSE总分之间存在显著关联（= 0.04）。平均而言，MMSE得分每增加1分，总体综合得分就增加0.40个单位（95%置信区间：0.03 - 0.77）。
讨论
视觉功能下降应引发对认知衰退的担忧，并促使进行进一步评估。
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