Department of Biochemistry, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey.
Department of Psychiatry, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale, Turkey.
Prog Neuropsychopharmacol Biol Psychiatry. 2023 Apr 20;123:110719. doi: 10.1016/j.pnpbp.2023.110719. Epub 2023 Jan 10.
Thiol-disulfide couple maintains an intracellular redox status. Dynamic thiol-disulfide homeostasis acts crucial parts in metabolic processes involving signal mechanisms, inflammation, antioxidant defense. Thiol-disulfide homeostasis have been implicated in numerous diseases. In this comprehensive review we identified the studies that examined the thiol-disulfide homeostasis in psychiatric disorders. Most cases demonstrated alterations in thiol-disulfide homeostasis and in most of them the thiol-disulfide balance tended to change direction to the disulfide side, that is, to the oxidative side. Currently, the fact that N-acetylcysteine, a thiol-containing compound, is of great interest as a new treatment approach in psychiatric disorders and the role of glutathione, the most abundant thiol, in the brain highlights the importance of evaluating the thiol-disulfide balance in psychiatric disorders.
巯基-二硫键体系维持着细胞内的氧化还原状态。动态巯基-二硫键动态平衡在涉及信号机制、炎症和抗氧化防御的代谢过程中起着至关重要的作用。巯基-二硫键动态平衡与许多疾病有关。在这篇全面的综述中，我们确定了研究精神障碍中巯基-二硫键动态平衡的研究。大多数情况下，巯基-二硫键动态平衡发生了改变，在大多数情况下，巯基-二硫键平衡倾向于向二硫键侧（即氧化侧）变化。目前，含巯基的化合物 N-乙酰半胱氨酸作为精神障碍新的治疗方法具有重要意义，以及脑内含量最丰富的巯基谷胱甘肽的作用，凸显了评估精神障碍中巯基-二硫键平衡的重要性。
