Khouchlaa Aya, El Baaboua Aicha, El Moudden Hamza, Lakhdar Fatima, Bakrim Saad, El Menyiy Naoual, Belmehdi Omar, Harhar Hicham, El Omari Nasreddine, Balahbib Abdelaali, Park Moon Nyeo, Zengin Gokhan, Kim Bonglee, Bouyahya Abdelhakim
Laboratory of Biochemistry, National Agency of Medicinal and Aromatic Plants, 34025 Taounate, Morocco.
Biology and Health Laboratory, Department of Biology, Faculty of Science, Abdelmalek-Essaadi University, Tetouan, Morocco.
Adv Pharmacol Pharm Sci. 2023 Jan 3;2023:2482544. doi: 10.1155/2023/2482544. eCollection 2023.
L. (Asteraceae) is a famous ornamental and medicinal plant widely distributed in Mediterranean countries and the southern region of Europe. This reputed species is widely used in traditional medicine in the treatment of many disorders and has various bioactivities, especially anti-inflammatory, antiviral, antimutagenic, antimicrobial, insecticidal, antioxidant, and immunomodulatory activities. The present review was conducted to provide a critical review of the comprehensive and current knowledge regarding species, in particular, its taxonomy and geographical distribution, botanical description, medicinal uses, phytochemical compounds, pharmacological properties, and toxicity investigations. The data collected on were obtained using different scientific research databases such as PubMed, SciFinder, SpringerLink, Web of Science, Science Direct, Google Scholar, Wiley Online, and Scopus. Phytochemical screening of different extracts and essential oils showed their richness in bioactive compounds, particularly in fatty acids, sterols, phenolics, flavonoids, saponins, tannins, alkaloids, and terpenoid compounds. The findings of this review showed that the pharmacological activities of confirm its importance and diversity as a traditional remedy for many diseases. This plant presents a wide range of bioactivities, namely, anti-inflammatory, antimicrobial, antitrypanosomial, antitumoral, antimutagenic, and immunomodulatory activities, as well as hemolytic properties and wound treatment. Nevertheless, pharmacokinetic validation and toxicological examinations are required to detect any possible toxicity for future clinical trials.
菊科的[植物名称]是一种著名的观赏和药用植物，广泛分布于地中海国家和欧洲南部地区。这种著名的植物在传统医学中被广泛用于治疗多种疾病，具有多种生物活性，特别是抗炎、抗病毒、抗诱变、抗菌、杀虫、抗氧化和免疫调节活性。本综述旨在对有关[植物名称]的全面和最新知识进行批判性综述，特别是其分类学和地理分布、植物描述、药用用途、植物化学成分、药理特性和毒性研究。关于[植物名称]收集的数据是使用不同的科学研究数据库获得的，如PubMed、SciFinder、SpringerLink、Web of Science、ScienceDirect、Google Scholar、Wiley Online和Scopus。对不同[植物名称]提取物和精油的植物化学筛选表明，它们富含生物活性化合物，特别是脂肪酸、甾醇、酚类、黄酮类、皂苷、单宁、生物碱和萜类化合物。本综述的结果表明，[植物名称]的药理活性证实了其作为许多疾病传统疗法的重要性和多样性。这种植物具有广泛的生物活性，即抗炎、抗菌、抗锥虫、抗肿瘤、抗诱变和免疫调节活性，以及溶血特性和伤口治疗作用。然而，需要进行药代动力学验证和毒理学检查，以检测未来临床试验中任何可能的毒性。
