Vashi Aditya, Sreejith Kamalalayam Rajan, Nguyen Nam-Trung
Queensland Micro- and Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia.
Micromachines (Basel). 2022 Dec 31;14(1):116. doi: 10.3390/mi14010116.
Gravity plays an important role in the development of life on earth. The effect of gravity on living organisms can be investigated by controlling the magnitude of gravity. Most reduced gravity experiments are conducted on the Lower Earth Orbit (LEO) in the International Space Station (ISS). However, running experiments in ISS face challenges such as high cost, extreme condition, lack of direct accessibility, and long waiting period. Therefore, researchers have developed various ground-based devices and methods to perform reduced gravity experiments. However, the advantage of space conditions for developing new drugs, vaccines, and chemical applications requires more attention and new research. Advancements in conventional methods and the development of new methods are necessary to fulfil these demands. The advantages of Lab-on-a-Chip (LOC) devices make them an attractive option for simulating microgravity. This paper briefly reviews the advancement of LOC technologies for simulating microgravity in an earth-based laboratory.
重力在地球上生命的发展过程中起着重要作用。通过控制重力大小，可以研究重力对生物体的影响。大多数微重力实验是在国际空间站（ISS）的近地轨道（LEO）上进行的。然而，在国际空间站上进行实验面临着诸如成本高、条件极端、缺乏直接可达性以及等待时间长等挑战。因此，研究人员开发了各种地面设备和方法来进行微重力实验。然而，太空条件在开发新药、疫苗和化学应用方面的优势需要更多关注和新的研究。为满足这些需求，传统方法的进步和新方法的开发是必要的。芯片实验室（LOC）设备的优势使其成为模拟微重力的一个有吸引力的选择。本文简要回顾了在地面实验室中用于模拟微重力的LOC技术的进展。
