Mohr E, Fabbrini G, Ruggieri S, Fedio P, Chase T N
Medical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
J Neurol Neurosurg Psychiatry. 1987 Sep;50(9):1192-6. doi: 10.1136/jnnp.50.9.1192.
Verbal, visuospatial and motor functions were studied in eight Parkinsonian patients both during levodopa stimulated and unstimulated state and in eight matched, untreated, healthy controls. Profound changes in patients' motor status were accompanied by relatively selective effects on delayed verbal memory, a function which was also most impaired compared with controls. With dopaminomimetic therapy, tests of delayed verbal memory consistently improved, but did not reach control performance levels. These results could indicate a functional impairment in the mesocortical dopamine system, which can be attenuated, but not entirely corrected, by dopaminomimetic therapy.
对8名帕金森病患者在左旋多巴刺激和未刺激状态下的语言、视觉空间和运动功能进行了研究，并与8名匹配的未经治疗的健康对照者进行了对比。患者运动状态的显著变化伴随着对延迟语言记忆的相对选择性影响，与对照组相比，这一功能也受损最为严重。采用拟多巴胺疗法后，延迟语言记忆测试结果持续改善，但未达到对照组的表现水平。这些结果可能表明中脑皮质多巴胺系统存在功能损害，拟多巴胺疗法可使其减轻，但不能完全纠正。
