Al-Kuraishy Hayder M, Al-Gareeb Ali I, Hetta Helal F, Alexiou Athanasios, Papadakis Marios, Batiha Gaber El-Saber
Department of Clinical Pharmacology and Therapeutic Medicine, College of Medicine, ALmustansiriyiah University, Baghdad, Iraq.
Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.
AMB Express. 2023 Jan 27;13(1):13. doi: 10.1186/s13568-023-01517-y.
Heparanase (HPSE) is an endoglycosidase cleaves heparan sulfate (HS) and this contributes to the degradation and remodeling of the extracellular matrix. HS cleaved by HPSE induces activation of autophagy and formation of autophagosommes which facilitate binding of HPSE to the HS and subsequent release of growth factors. The interaction between HPSE and HS triggers releases of chemokines and cytokines which affect inflammatory response and cell signaling pathways with development of hyperinflammation, cytokine storm (CS) and coagulopathy. HPSE expression is induced by both SARS-CoV-2 and monkeypox virus (MPXV) leading to induction release of pro-inflammatory cytokines, endothelial dysfunction and thrombotic events. Co-infection of MPX with SARS-CoV-2 may occur as we facing many outbreaks of MPX cases during Covid-19 pandemic. Therefore, targeting of HPSE by specific inhibitors may reduce the risk of complications in both SARS-CoV-2 and MPXV infections. Taken together, HPSE could be a potential link between MPX with SARS-CoV-2 in Covid-19 era.
乙酰肝素酶（HPSE）是一种内切糖苷酶，可切割硫酸乙酰肝素（HS），这有助于细胞外基质的降解和重塑。被HPSE切割的HS会诱导自噬激活和自噬体形成，这有助于HPSE与HS结合以及随后生长因子的释放。HPSE与HS之间的相互作用会触发趋化因子和细胞因子的释放，这些因子会影响炎症反应和细胞信号通路，进而导致过度炎症、细胞因子风暴（CS）和凝血病的发展。HPSE的表达由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）和猴痘病毒（MPXV）诱导，导致促炎细胞因子的诱导释放、内皮功能障碍和血栓形成事件。在2019冠状病毒病大流行期间，由于我们面临许多猴痘病例的爆发，MPX与SARS-CoV-2可能会发生共同感染。因此，用特异性抑制剂靶向HPSE可能会降低SARS-CoV-2和MPXV感染并发症的风险。综上所述，在2019冠状病毒病时代，HPSE可能是MPX与SARS-CoV-2之间的潜在联系。
