Pezato Rogério, David Andrea Goldwasser, Boggi Alexandre Coelho, Melo Bruna, Rosalino Claudia Maria Valete, Rodriguez Athenea Pascual, Thamboo Andrew, Voegels Richard Louis
Av. Prof. Lineu Prestes, 2565 - Butantã, São Paulo, SP 05508-000 Brazil Departament of Ophathalmology and Otorhinolaryngology, University of Sao Paulo.
Vancouver, BC Canada Centre of Heart Lung Innovation, University of British Columbia.
Indian J Otolaryngol Head Neck Surg. 2023 Jun;75(2):772-776. doi: 10.1007/s12070-022-03426-1. Epub 2023 Jan 19.
Covid-19 is transmitted mainly by respiratory droplets and as the upper airway mucosa is the first innate immune barrier, it is crucial to understand the effects of SARS-CoV-2 on this system. In the current study, we aimed to evaluate the nasal mucociliary clearance in patients with SARS-CoV-2 infection and their symptom development. Observational cross-sectional study. The nasal mucociliary clearance (NMC) time was evaluated by the saccharin test and the results were compared between patients with SARS-CoV-2 infection (group 1) and controls (group 2, asymptomatic patients with a negative polymerase chain reaction test). We also compared the NMC time for each specific symptom suffered by participants in group 1 with the NMC time of the control group as well as with the patients in group 1 who were asymptomatic. There was a significant increase in NMC time in group 1 with dyspnea when compared to the control group ( = 0.032) and also when compared to patients who were infected were not dyspneic ( = 0.04). There were no differences in the clearance times when considering other symptoms. COVID-19 patients with dyspnea present with altered nasal mucociliary clearance.
新冠病毒主要通过呼吸道飞沫传播，由于上呼吸道黏膜是第一道固有免疫屏障，了解严重急性呼吸综合征冠状病毒2（SARS-CoV-2）对该系统的影响至关重要。在本研究中，我们旨在评估SARS-CoV-2感染患者的鼻黏液纤毛清除功能及其症状发展情况。观察性横断面研究。通过糖精试验评估鼻黏液纤毛清除（NMC）时间，并比较SARS-CoV-2感染患者（第1组）和对照组（第2组，聚合酶链反应检测阴性的无症状患者）的结果。我们还比较了第1组参与者出现的每种特定症状的NMC时间与对照组的NMC时间，以及与第1组无症状患者的NMC时间。与对照组相比（P = 0.032），以及与未出现呼吸困难的感染患者相比（P = 0.04），第1组出现呼吸困难时的NMC时间显著增加。考虑其他症状时，清除时间没有差异。出现呼吸困难的新冠病毒感染患者存在鼻黏液纤毛清除功能改变。
