: “死亡之师”的队长和经济负担。
: 'captain of the men of death' and financial burden.
机构信息
Department of Respiratory Sciences, University of Leicester, Leicester LE1 7RH, UK.
Department of Genetics, University of Leicester, Leicester LE1 7RH, UK.
出版信息
Microbiology (Reading). 2022 Dec;168(12). doi: 10.1099/mic.0.001275.
Abstract
may inhabit the upper respiratory tract of humans without causing harm but it also causes diseases with high morbidity and mortality. It has excellent adaptive capabilities thanks to its ability to shuffle its genetic content by acquiring and incorporating DNA from other bacteria and is highly competent for genetic transformation. Sugar sensing, cleavage and transport ensure its fitness and survival in the host, and intracellular survival in macrophages has been linked to virulence. The polysaccharide capsule and toxin pneumolysin are the most important virulence determinants. Polysaccharide-based vaccines provide protection against the serotypes represented in vaccine formulations.
摘要
它可能寄居在人类的上呼吸道而不造成伤害，但也会引起高发病率和死亡率的疾病。它具有出色的适应能力，能够通过获取和整合来自其他细菌的 DNA 来改变其遗传物质，并且非常擅长遗传转化。糖感应、切割和运输确保了它在宿主中的适应性和生存能力，而在巨噬细胞内的存活与毒力有关。多糖荚膜和毒素肺炎球菌溶血素是最重要的毒力决定因素。基于多糖的疫苗为疫苗配方中所代表的血清型提供保护。
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