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基于免疫分析的真菌毒素分析和毒理基因组学技术的最新进展。

Recent advances in immunoassay-based mycotoxin analysis and toxicogenomic technologies.

机构信息

Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.

出版信息

J Food Drug Anal. 2022 Nov 23;30(4):549-561. doi: 10.38212/2224-6614.3430.

Abstract

The co-occurrence and accumulation of mycotoxin in food and feed constitutes a major issue to food safety, food security, and public health. Accurate and sensitive mycotoxins analysis can avoid toxin contamination as well as reduce food wastage caused by false positive results. This mini review focuses on the recent advance in detection methods for multiple mycotoxins, which mainly depends on immunoassay technologies. Advance immunoassay technologies integrated in mycotoxin analysis enable simultaneous detection of multiple mycotoxins and enhance the outcomes' quality. It highlights toxicogenomic as novel approach for hazard assessment by utilizing computational methods to map molecular events and biological processes. Indeed, toxicogenomic is a powerful tool to understand health effects from mycotoxin exposure as it offers insight on the mechanisms by which mycotoxins exposures cause diseases.

摘要

真菌毒素在食品和饲料中的共同出现和积累是食品安全、粮食安全和公共卫生的主要问题。准确和敏感的真菌毒素分析可以避免毒素污染,并减少因假阳性结果而导致的食物浪费。本综述重点介绍了真菌毒素检测方法的最新进展,这些方法主要依赖于免疫测定技术。集成在真菌毒素分析中的先进免疫测定技术能够同时检测多种真菌毒素,并提高结果的质量。它强调了毒理学基因组学作为一种通过利用计算方法来映射分子事件和生物过程来进行危害评估的新方法。事实上,毒理学基因组学是了解真菌毒素暴露对健康影响的有力工具,因为它提供了关于真菌毒素暴露导致疾病的机制的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/475e/9910299/d45ee4a7cb88/jfda-30-04-549f1.jpg

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