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从(迈阿密粉)纸花中合成的生物源银纳米材料的治疗应用

Therapeutic Applications of Biogenic Silver Nanomaterial Synthesized from the Paper Flower of (Miami, Pink).

作者信息

Oves Mohammad, Rauf Mohd Ahmar, Qari Huda A

机构信息

Centre of Excellence in Environmental Studies, King Abdulaziz University, Jeddah 22252, Saudi Arabia.

Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

出版信息

Nanomaterials (Basel). 2023 Feb 3;13(3):615. doi: 10.3390/nano13030615.

Abstract

In this research, paper flower extract was used to quickly synthesize biogenic silver nanoparticles (BAgNPs) utilizing green chemistry. Using the flower extract as a biological reducing agent, silver nanoparticles were generated by the conversion of Ag cations to Ag ions. Data patterns obtained from physical techniques for characterizing BAgNPs, employing UV-visible, scattering electron microscope (SEM), transmission electron microscope (TEM), dynamic light scattering (DLS), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR), suggested that the nanoparticles have a spherical to oval form with size ranging from 10 to 50 nm. Spectroscopy and microscopic analysis were used to learn more about the antibacterial properties of the biologically produced BAgNPs from . Further, the potential mechanism of action of nanoparticles was investigated by studying their interactions in vitro with several bacterial strains and mammalian cancer cell systems. Finally, we can conclude that BAgNPs can be functionalized to dramatically inhibit bacterial growth and the growth of cancer cells in culture conditions, suggesting that biologically produced nanomaterials will provide new opportunities for a wide range of biomedical applications in the near future.

摘要

在本研究中,利用绿色化学方法,使用纸花提取物快速合成生物银纳米颗粒(BAgNPs)。以花提取物作为生物还原剂,通过将银阳离子转化为银离子来生成银纳米颗粒。利用紫外可见光谱、扫描电子显微镜(SEM)、透射电子显微镜(TEM)、动态光散射(DLS)、X射线衍射(XRD)和傅里叶变换红外光谱(FTIR)等物理技术对BAgNPs进行表征所获得的数据模式表明,这些纳米颗粒呈球形至椭圆形,尺寸范围为10至50纳米。通过光谱学和显微镜分析进一步了解了生物合成的BAgNPs的抗菌特性。此外,通过研究纳米颗粒在体外与几种细菌菌株和哺乳动物癌细胞系统的相互作用,探讨了其潜在的作用机制。最后,我们可以得出结论,BAgNPs可以被功能化,从而在培养条件下显著抑制细菌生长和癌细胞生长,这表明生物合成的纳米材料在不久的将来将为广泛的生物医学应用提供新的机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cffd/9920917/48afc0695336/nanomaterials-13-00615-g001.jpg

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