环磷酰胺对远交系无胸腺（裸）小鼠体内针对非胸腺依赖性抗原（二硝基苯基-聚合人γ球蛋白-聚蔗糖）反应的影响。
Effects of cyclophosphamide on the in vivo response of outbred athymic (nude) mice to a thymus-independent antigen (DNP-AGG-Ficoll).
作者信息
Snippe H, Merchant B, Johannessen L, Inman J K
出版信息
Immunology. 1978 Dec;35(6):1009-15.
Both nude mice (nu/nu) and their heterozygous littermates (nu/+) were injected with a single IP dose of 300 mg cyclophosphamide (CY)/kg. CY is a known immunosuppressive agent, which affects primarily B lymphocytes. Immunization with the thymus independent antigen DNP-AGG59-Ficoll after CY treatment disclosed that restoration of the primary direct PFC response occurred more rapidly in nude mice than in nu/+ mice. However in these same experiments, the primary indirect PFC response, recovered earlier in nu/+ mice than in nude mice. After CY treatment, secondary indirect PFC responses were delayed in both nude and nu/+ mice, but the greatest effect was seen in nude mice. The data suggest that the presence of T cells has little if any influence on the recovery capacity of those B cells which are destined to become direct PFC. However the recovery of B cells which are destined to produce indirect PFC responses is facilitated by the presence of T cells.
将300毫克环磷酰胺（CY）/千克的单一腹腔注射剂量注射给裸鼠（nu/nu）及其杂合子同窝小鼠（nu/+）。CY是一种已知的免疫抑制剂，主要影响B淋巴细胞。CY处理后用胸腺非依赖性抗原DNP-AGG59-菲可进行免疫，结果显示，裸鼠中初级直接PFC反应的恢复比nu/+小鼠更快。然而，在相同的实验中，初级间接PFC反应在nu/+小鼠中比在裸鼠中恢复得更早。CY处理后，裸鼠和nu/+小鼠的次级间接PFC反应均延迟，但在裸鼠中观察到的影响最大。数据表明，T细胞的存在对那些注定要成为直接PFC的B细胞的恢复能力几乎没有影响。然而，T细胞的存在促进了注定产生间接PFC反应的B细胞的恢复。
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