Abo-Shady Atef Mohamed, Gheda Saly Farouk, Ismail Gehan Ahmed, Cotas João, Pereira Leonel, Abdel-Karim Omnia Hamdy
Botany Department, Faculty of Science, Tanta University, Tanta 31527, Egypt.
MARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal.
Life (Basel). 2023 Feb 7;13(2):460. doi: 10.3390/life13020460.
Currently, algae arouse a growing interest in the pharmaceutical and cosmetic area due to the fact that they have a great diversity of bioactive compounds with the potential for pharmacological and nutraceutical applications. Due to lifestyle modifications brought on by rapid urbanization, diabetes mellitus, a metabolic illness, is the third largest cause of death globally. The hunt for an efficient natural-based antidiabetic therapy is crucial to battling diabetes and the associated consequences due to the unfavorable side effects of currently available antidiabetic medications. Finding the possible advantages of algae for the control of diabetes is crucial for the creation of natural drugs. Many of algae's metabolic processes produce bioactive secondary metabolites, which give algae their diverse chemical and biological features. Numerous studies have demonstrated the antioxidant and antidiabetic benefits of algae, mostly by blocking carbohydrate hydrolyzing enzyme activity, such as α-amylase and α-glucosidase. Additionally, bioactive components from algae can lessen diabetic symptoms in vivo. Therefore, the current review concentrates on the role of various secondary bioactive substances found naturally in algae and their potential as antioxidants and antidiabetic materials, as well as the urgent need to apply these substances in the pharmaceutical industry.
目前,藻类在制药和化妆品领域引起了越来越多的关注,因为它们含有种类繁多的生物活性化合物,具有药理学和营养保健应用的潜力。由于快速城市化带来的生活方式改变,糖尿病作为一种代谢性疾病,是全球第三大死因。寻找一种有效的天然抗糖尿病疗法对于对抗糖尿病以及应对当前可用抗糖尿病药物的不良副作用所带来的相关后果至关重要。发现藻类对控制糖尿病的潜在益处对于天然药物的研发至关重要。藻类的许多代谢过程会产生生物活性次生代谢产物,这些产物赋予了藻类多样的化学和生物学特性。众多研究已证明藻类具有抗氧化和抗糖尿病的益处,主要是通过抑制碳水化合物水解酶的活性,如α-淀粉酶和α-葡萄糖苷酶。此外,藻类中的生物活性成分可在体内减轻糖尿病症状。因此,本综述重点关注藻类中天然存在的各种次生生物活性物质的作用及其作为抗氧化剂和抗糖尿病材料的潜力,以及将这些物质应用于制药行业的迫切需求。