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含有[具体植物名称]乙醇提取物的细菌纤维素膜的抗癌特性 。 注：原文中“. ”处信息缺失，这里只是根据格式要求进行了大致翻译，实际完整准确的翻译需补充完整提取物来源等信息。

Anticancer properties of bacterial cellulose membrane containing ethanolic extract of .

作者信息

Perużyńska Magdalena, Nowak Anna, Birger Radosław, Ossowicz-Rupniewska Paula, Konopacki Maciej, Rakoczy Rafał, Kucharski Łukasz, Wenelska Karolina, Klimowicz Adam, Droździk Marek, Kurzawski Mateusz

机构信息

Department of Experimental and Clinical Pharmacology, Pomeranian Medical University in Szczecin, Szczecin, Poland.

Department of Cosmetic and Pharmaceutical Chemistry, Pomeranian Medical University in Szczecin, Szczecin, Poland.

出版信息

Front Bioeng Biotechnol. 2023 Feb 20;11:1133345. doi: 10.3389/fbioe.2023.1133345. eCollection 2023.

DOI:10.3389/fbioe.2023.1133345
PMID:36890919
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9986418/
Abstract

is a medicinal plant well known for its anti-inflammatory, antibacterial, antioxidant, and anticancer properties related to its high polyphenols content. In the present study, we evaluated the antiproliferative properties of ethanolic extract of (EAE) against normal human fibroblasts (HDF) and selected cancer cell lines, including melanoma (A375), breast (MCF7), colon (HT-29), lung (A549) and liver (HepG2). Next, bacterial cellulose (BC) membranes were applied as a matrix for the controlled delivery of the plant extract (BC-EAE) and characterized by thermogravimetry (TG), infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) images. In addition, EAE loading and kinetic release were defined. Finally, the anticancer activity of BC-EAE was evaluated against the HT-29 cell line, which presented the highest sensitivity to the tested plant extract (IC = 61.73 ± 6.42 µM). Our study confirmed the biocompatibility of empty BC and the dose and time-dependent cytotoxicity of the released EAE. The plant extract released from BC-2.5%EAE significantly reduced cell viability to 18.16% and 6.15% of the control values and increased number apoptotic/dead cells up to 37.53% and 66.90% after 48 and 72 h of treatment, respectively. In conclusion, our study has shown that BC membranes could be used as a carrier for the delivery of higher doses of anticancer compounds released in a sustained manner in the target tissue.

摘要

是一种药用植物，因其高多酚含量而具有抗炎、抗菌、抗氧化和抗癌特性而闻名。在本研究中，我们评估了[植物名称]乙醇提取物（EAE）对正常人成纤维细胞（HDF）和选定癌细胞系的抗增殖特性，包括黑色素瘤（A375）、乳腺癌（MCF7）、结肠癌（HT - 29）、肺癌（A549）和肝癌（HepG2）。接下来，应用细菌纤维素（BC）膜作为植物提取物（BC - EAE）控释的基质，并通过热重分析（TG）、红外光谱（FTIR）和扫描电子显微镜（SEM）图像进行表征。此外，还确定了EAE的负载量和动力学释放情况。最后，评估了BC - EAE对HT - 29细胞系的抗癌活性，该细胞系对测试的植物提取物表现出最高的敏感性（IC = 61.73 ± 6.42 μM）。我们的研究证实了空BC的生物相容性以及释放的EAE的剂量和时间依赖性细胞毒性。从BC - 2.5%EAE释放的植物提取物在处理48小时和72小时后，分别将细胞活力显著降低至对照值的18.16%和6.15%，并使凋亡/死亡细胞数量分别增加至37.53%和66.90%。总之，我们的研究表明，BC膜可作为载体，用于递送在靶组织中持续释放的更高剂量抗癌化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42bd/9986418/68a122784276/fbioe-11-1133345-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42bd/9986418/ed6f013d894a/fbioe-11-1133345-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42bd/9986418/aa84df7c736c/fbioe-11-1133345-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42bd/9986418/4b424b6dac20/fbioe-11-1133345-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42bd/9986418/fc2aa330bc2c/fbioe-11-1133345-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42bd/9986418/6735b4586b12/fbioe-11-1133345-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42bd/9986418/7b9e695bfacb/fbioe-11-1133345-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42bd/9986418/68a122784276/fbioe-11-1133345-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42bd/9986418/0e399df3bce7/fbioe-11-1133345-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42bd/9986418/aa84df7c736c/fbioe-11-1133345-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42bd/9986418/4b424b6dac20/fbioe-11-1133345-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42bd/9986418/fc2aa330bc2c/fbioe-11-1133345-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42bd/9986418/45021ccf461c/fbioe-11-1133345-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42bd/9986418/6735b4586b12/fbioe-11-1133345-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42bd/9986418/cf74ee0475d1/fbioe-11-1133345-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42bd/9986418/7b9e695bfacb/fbioe-11-1133345-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42bd/9986418/68a122784276/fbioe-11-1133345-g011.jpg

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