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神经型莱姆病:不寻常的临床表现及影像学特征。

Neuroborreliosis: Unusual clinical presentation and imaging features.

作者信息

Kashyap Manshi, Kashyap Priyanka Vikas

机构信息

Department of Neurology, AIIMS, Bhopal, Madhya Pradesh, India.

出版信息

J Neurosci Rural Pract. 2023 Jan-Mar;14(1):132-136. doi: 10.25259/JNRP-2022-7-4. Epub 2022 Dec 29.

DOI:10.25259/JNRP-2022-7-4
PMID:36891091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9945291/
Abstract

Lyme disease is a tick-borne infectious disease caused by which causes a multi-organ involvement. It is endemic in North America and Europe, but not very commonly seen in India. Neurological manifestations (Lyme's Neuroborreliosis,) can occur in both the early and late disseminated stages, and the classic triad consists of aseptic meningitis, painful radiculoneuritis, and cranial neuropathy. If untreated, it can be fatal and may lead to significant morbidity. We report a case with neuroborreliosis who developed acute onset and rapidly progressive bilateral vision loss, and we also report characteristic features on neuroimaging, including a characteristic "rounded M sign." This unusual presentation, along with the characteristic imaging features, should be borne in mind to avoid misdiagnosis.

摘要

莱姆病是一种由蜱传播的传染病,可导致多器官受累。它在北美和欧洲流行,但在印度不太常见。神经表现(莱姆神经疏螺旋体病)可发生在早期和晚期播散阶段,典型三联征包括无菌性脑膜炎、疼痛性神经根神经炎和颅神经病变。如果不治疗,可能会致命,并可能导致严重的发病率。我们报告一例神经疏螺旋体病患者,其急性起病并迅速进展为双侧视力丧失,我们还报告了神经影像学的特征性表现,包括特征性的“圆形M征”。应牢记这种不寻常的表现以及特征性的影像学特征,以避免误诊。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7808/9945291/5284cf7769a3/JNRP-14-132-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7808/9945291/3b5073377ca8/JNRP-14-132-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7808/9945291/ca5cf74c473a/JNRP-14-132-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7808/9945291/4c56f1cb4a49/JNRP-14-132-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7808/9945291/5284cf7769a3/JNRP-14-132-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7808/9945291/3b5073377ca8/JNRP-14-132-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7808/9945291/ca5cf74c473a/JNRP-14-132-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7808/9945291/4c56f1cb4a49/JNRP-14-132-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7808/9945291/5284cf7769a3/JNRP-14-132-g004.jpg

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本文引用的文献

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Brainstem encephalitis in neuroborreliosis: typical clinical course and distinct MRI findings.神经莱姆病性脑干脑炎:典型临床经过和独特的 MRI 表现。
J Neurol. 2021 Feb;268(2):502-505. doi: 10.1007/s00415-020-10188-9. Epub 2020 Aug 28.
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Imaging in Lyme neuroborreliosis.莱姆病神经螺旋体病的影像学检查
Insights Imaging. 2018 Oct;9(5):833-844. doi: 10.1007/s13244-018-0646-x. Epub 2018 Sep 4.
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Common and uncommon neurological manifestations of neuroborreliosis leading to hospitalization.导致住院的神经型莱姆病常见和不常见的神经表现。
BMC Infect Dis. 2017 Jan 21;17(1):90. doi: 10.1186/s12879-016-2112-z.
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Neuro-lyme disease: MR imaging findings.神经型莱姆病:磁共振成像表现
Radiology. 2009 Oct;253(1):167-73. doi: 10.1148/radiol.2531081103. Epub 2009 Jul 8.
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Lyme neuroborreliosis: manifestations of a rapidly emerging zoonosis.莱姆病神经螺旋体病:一种迅速出现的人畜共患病的表现
AJNR Am J Neuroradiol. 2009 Jun;30(6):1079-87. doi: 10.3174/ajnr.A1579. Epub 2009 Apr 3.
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Recommendations for test performance and interpretation from the Second National Conference on Serologic Diagnosis of Lyme Disease.第二届莱姆病血清学诊断全国会议关于检测操作与结果解读的建议。
MMWR Morb Mortal Wkly Rep. 1995 Aug 11;44(31):590-1.
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Biopsy-confirmed CNS Lyme disease: MR appearance at 1.5 T.活检确诊的中枢神经系统莱姆病:1.5T磁共振成像表现
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