Al-sieni Abdulbasit I I
Biochemistry Department, Faculty of Science, King Abdulaziz University, P. O. Box 12161, Jeddah 21473, Saudi Arabia.
Afr J Tradit Complement Altern Med. 2013 Nov 2;11(1):23-7. eCollection 2014.
Nowadays there is a need to find naturally occurring substances from plants with antimicrobial activity as an alternative to available used antibiotics.
Salvadora persica (miswak) and Commiphora gileadensis were collected, dried and extracted with either methanol or warm water and the obtained extracts were assessed for their antibacterial activity against 5 different genera of bacteria using agar well diffusion method. The tested bacteria included some human pathogens.
The obtained extracts exhibited considerable inhibitory effects against all the tested bacteria with various degrees of growth inhibition. It was shown that methanol extract was more effective compared to water extracts. The minimum inhibitory concentrations (MIC) of the methanol extracts ranged from 50-100 °g/ml. No toxicity was found using Artimia salina as test organism and no antitumor activity against Ehrlich ascites carcinoma.
S. persica and C. gileadensis showed moderate to high inhibitory activity on pathogenic bacteria with no toxicity and can be used traditionally as alternative medicine.
如今，有必要从植物中寻找具有抗菌活性的天然物质，以替代现有的抗生素。
收集了没药树（牙刷树）和乳香黄连木，进行干燥处理，然后用甲醇或温水进行提取。使用琼脂孔扩散法评估所得提取物对5种不同属细菌的抗菌活性。所测试的细菌包括一些人类病原体。
所得提取物对所有测试细菌均表现出相当程度的抑制作用，且抑制生长程度各异。结果表明，甲醇提取物比水提取物更有效。甲醇提取物的最低抑菌浓度（MIC）范围为50 - 100μg/ml。以卤虫为受试生物未发现毒性，对艾氏腹水癌也无抗肿瘤活性。
没药树和乳香黄连木对病原菌表现出中度至高抑制活性，且无毒性，可作为传统替代药物使用。
