High-Content Based Hydrogels: Physicochemical and Pharmaceutical Properties.

The present research focuses on the physicochemical and pharmacotechnical properties of new hydrogels obtained using allantoin, xanthan gum, salicylic acid and different concentrations of (5, 10, 20% / in solution; 38, 56, 71 wt% in dry gels). The thermal behavior of composite hydrogels was studied using DSC and TG/DTG analyses. The chemical structure was investigated using different characterization methods (XRD, FTIR and Raman spectroscopies) and the morphology of the hydrogels was studied SEM and AFM microscopy. Pharmacotechnical evaluation on tensile strength and elongation, moisture content, swelling and spreadability was also completed. Physical evaluation confirmed that the appearance of the prepared based hydrogels was homogeneous and the color varied from pale beige to deep opaque beige with increasing concentration. All other evaluation parameters, e.g., pH, viscosity, spreadability and consistency were found to be adequate in all hydrogel formulations. SEM and AFM images show that the structure of the hydrogels condensed into homogeneous polymeric solids with the addition of , in accordance with the decrease in peak intensities observed via XRD analysis. These results suggest interactions between the hydrogel matrix and as observed via FTIR and TG/DTG and DSC analyses. Considering that content higher than 10% (/) did not stimulate further interactions, this formulation (FA-10) can be used for further biomedical applications.