Chelu Mariana, Popa Monica, Ozon Emma Adriana, Pandele Cusu Jeanina, Anastasescu Mihai, Surdu Vasile Adrian, Calderon Moreno Jose, Musuc Adina Magdalena
"Ilie Murgulescu" Institute of Physical Chemistry, 202 Spl. Independentei, 060021 Bucharest, Romania.
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania.
Polymers (Basel). 2023 Mar 6;15(5):1312. doi: 10.3390/polym15051312.
The present research focuses on the physicochemical and pharmacotechnical properties of new hydrogels obtained using allantoin, xanthan gum, salicylic acid and different concentrations of (5, 10, 20% / in solution; 38, 56, 71 wt% in dry gels). The thermal behavior of composite hydrogels was studied using DSC and TG/DTG analyses. The chemical structure was investigated using different characterization methods (XRD, FTIR and Raman spectroscopies) and the morphology of the hydrogels was studied SEM and AFM microscopy. Pharmacotechnical evaluation on tensile strength and elongation, moisture content, swelling and spreadability was also completed. Physical evaluation confirmed that the appearance of the prepared based hydrogels was homogeneous and the color varied from pale beige to deep opaque beige with increasing concentration. All other evaluation parameters, e.g., pH, viscosity, spreadability and consistency were found to be adequate in all hydrogel formulations. SEM and AFM images show that the structure of the hydrogels condensed into homogeneous polymeric solids with the addition of , in accordance with the decrease in peak intensities observed via XRD analysis. These results suggest interactions between the hydrogel matrix and as observed via FTIR and TG/DTG and DSC analyses. Considering that content higher than 10% (/) did not stimulate further interactions, this formulation (FA-10) can be used for further biomedical applications.
本研究聚焦于使用尿囊素、黄原胶、水杨酸以及不同浓度的（溶液中为5%、10%、20%；干凝胶中为38%、56%、71%重量比）所制备的新型水凝胶的物理化学和药剂学性质。采用差示扫描量热法（DSC）和热重/微商热重分析（TG/DTG）研究了复合水凝胶的热行为。使用不同的表征方法（X射线衍射（XRD）、傅里叶变换红外光谱（FTIR）和拉曼光谱）研究了化学结构，并通过扫描电子显微镜（SEM）和原子力显微镜（AFM）研究了水凝胶的形态。还完成了关于拉伸强度和伸长率、水分含量、溶胀性和铺展性的药剂学评价。物理评价证实，所制备的基于[具体物质]的水凝胶外观均匀，随着[具体物质]浓度的增加，颜色从浅米色变为深不透明米色。发现所有水凝胶配方中的所有其他评价参数，如pH值、粘度、铺展性和稠度均合适。SEM和AFM图像表明，随着[具体物质]的加入，水凝胶结构凝聚成均匀的聚合物固体，这与XRD分析中观察到的峰强度降低一致。这些结果表明，通过FTIR以及TG/DTG和DSC分析观察到水凝胶基质与[具体物质]之间存在相互作用。考虑到高于10%（/）的[具体物质]含量并未刺激进一步的相互作用，该配方（FA - 10）可用于进一步的生物医学应用。
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