Institute of Applied Sciences and Intelligent Systems, National Research Council of Italy, 73100 Lecce, Italy; University Paris-Est Cretéil, Laboratoire LISSI, 94400, Vitry sur Seine, Paris, France.
Institute of Applied Sciences and Intelligent Systems, National Research Council of Italy, 73100 Lecce, Italy.
Med Image Anal. 2023 May;86:102797. doi: 10.1016/j.media.2023.102797. Epub 2023 Mar 21.
Since the emergence of the Covid-19 pandemic in late 2019, medical imaging has been widely used to analyze this disease. Indeed, CT-scans of the lungs can help diagnose, detect, and quantify Covid-19 infection. In this paper, we address the segmentation of Covid-19 infection from CT-scans. To improve the performance of the Att-Unet architecture and maximize the use of the Attention Gate, we propose the PAtt-Unet and DAtt-Unet architectures. PAtt-Unet aims to exploit the input pyramids to preserve the spatial awareness in all of the encoder layers. On the other hand, DAtt-Unet is designed to guide the segmentation of Covid-19 infection inside the lung lobes. We also propose to combine these two architectures into a single one, which we refer to as PDAtt-Unet. To overcome the blurry boundary pixels segmentation of Covid-19 infection, we propose a hybrid loss function. The proposed architectures were tested on four datasets with two evaluation scenarios (intra and cross datasets). Experimental results showed that both PAtt-Unet and DAtt-Unet improve the performance of Att-Unet in segmenting Covid-19 infections. Moreover, the combination architecture PDAtt-Unet led to further improvement. To Compare with other methods, three baseline segmentation architectures (Unet, Unet++, and Att-Unet) and three state-of-the-art architectures (InfNet, SCOATNet, and nCoVSegNet) were tested. The comparison showed the superiority of the proposed PDAtt-Unet trained with the proposed hybrid loss (PDEAtt-Unet) over all other methods. Moreover, PDEAtt-Unet is able to overcome various challenges in segmenting Covid-19 infections in four datasets and two evaluation scenarios.
自 2019 年底新冠疫情爆发以来,医学影像学已广泛应用于分析这种疾病。事实上,肺部 CT 扫描有助于诊断、检测和量化新冠病毒感染。在本文中,我们致力于从 CT 扫描中分割新冠病毒感染。为了提高 Att-Unet 架构的性能并最大限度地利用注意力门,我们提出了 PAtt-Unet 和 DAtt-Unet 架构。PAtt-Unet 的目的是利用输入金字塔在所有编码器层中保留空间意识。另一方面,DAtt-Unet 旨在引导肺部肺叶内新冠病毒感染的分割。我们还提出将这两种架构组合成一个单一的架构,我们称之为 PDAtt-Unet。为了克服新冠病毒感染边界像素分割的模糊问题,我们提出了一种混合损失函数。所提出的架构在四个数据集上进行了测试,采用了两种评估场景(内部和交叉数据集)。实验结果表明,PAtt-Unet 和 DAtt-Unet 都提高了 Att-Unet 分割新冠病毒感染的性能。此外,组合架构 PDAtt-Unet 进一步提高了性能。为了与其他方法进行比较,测试了三个基线分割架构(Unet、Unet++ 和 Att-Unet)和三个最新的架构(InfNet、SCOATNet 和 nCoVSegNet)。比较表明,与其他方法相比,使用所提出的混合损失函数训练的 PDAtt-Unet(PDEAtt-Unet)具有优越性。此外,PDEAtt-Unet 能够克服四个数据集和两种评估场景中新冠病毒感染分割的各种挑战。