Rowicka Grażyna, Klemarczyk Witold, Ambroszkiewicz Jadwiga, Strucińska Małgorzata, Kawiak-Jawor Ewa, Weker Halina, Chełchowska Magdalena
Department of Nutrition, Institute of Mother and Child, 01-211 Warsaw, Poland.
Department of Screening Tests and Metabolic Diagnostics, Institute of Mother and Child, 01-211 Warsaw, Poland.
Antioxidants (Basel). 2023 Mar 10;12(3):682. doi: 10.3390/antiox12030682.
Oxidant-antioxidant balance is crucial for maintaining one's health, and the diet is possibly one of the most important factors affecting this balance. Therefore, the aim of this study was to determine the oxidant-antioxidant balance in children on a lacto-ovo-vegetarian diet. The study was conducted between January 2020 and December 2021. The concentrations of total oxidant capacity (TOC), total antioxidant capacity (TAC), reduced (GSH), and oxidized (GSSG) glutathione, as well as C-reactive protein (CRP) and calprotectin were measured in serum samples of 72 healthy prepubertal children (32 vegetarians and 40 omnivores). The oxidative stress index (OSI) and the GSH/GSSG ratio (R-index) were calculated. Children on a vegetarian diet had significantly lower median values of TOC, GSH, and GSSG, and higher TAC compared with the omnivores. OSI was significantly lower in vegetarians, while R-index, as well as median values of CRP and calprotectin did not differ between both groups of children. Significant negative correlations were observed between TOC and TAC levels in the whole group of children and in vegetarians. GSH and GSSG levels correlated positively in the groups of vegetarians, omnivores, and in all the children. There were significant positive correlations between TOC and GSH, as well as GSSG levels in all the studied groups of children. Our study results suggest that the vegetarian model of nutrition allows to maintain the oxidant-antioxidant balance in the serum of prepubertal children.
氧化还原平衡对于维持人体健康至关重要，而饮食可能是影响这种平衡的最重要因素之一。因此，本研究的目的是确定食用乳蛋素食的儿童的氧化还原平衡。该研究于2020年1月至2021年12月进行。在72名健康的青春期前儿童（32名素食者和40名杂食者）的血清样本中测量了总氧化能力（TOC）、总抗氧化能力（TAC）、还原型（GSH）和氧化型（GSSG）谷胱甘肽的浓度，以及C反应蛋白（CRP）和钙卫蛋白。计算了氧化应激指数（OSI）和GSH/GSSG比值（R指数）。与杂食者相比，素食儿童的TOC、GSH和GSSG的中位数显著较低，而TAC较高。素食儿童的OSI显著较低，而两组儿童的R指数以及CRP和钙卫蛋白的中位数没有差异。在整个儿童组和素食儿童中，TOC和TAC水平之间存在显著的负相关。在素食者、杂食者和所有儿童组中，GSH和GSSG水平呈正相关。在所有研究的儿童组中，TOC与GSH以及GSSG水平之间存在显著的正相关。我们的研究结果表明，素食营养模式有助于维持青春期前儿童血清中的氧化还原平衡。
