Saloň Adam, Steuber Bianca, Neshev Ruslan, Schmid-Zalaudek Karin, De Boever Patrick, Bergmann Eva, Picha Rainer, Fredriksen Per Morten, Nkeh-Chungag Benedicta Ngwechi, Goswami Nandu
Gravitational Physiology and Medicine Research Unit, Division of Physiology, Otto Loewi Research Center, Medical University of Graz, 8036 Graz, Austria.
Faculty of Health and Social Sciences, Inland Norway University of Applied Science, 2624 Lillehammer, Norway.
J Clin Med. 2023 Mar 13;12(6):2229. doi: 10.3390/jcm12062229.
(1) Background: Studies have reported the effectiveness of light therapy in various medical conditions. Our pilot study aimed to assess the effect of Maharishi light therapy (MLT) on physiological parameters, such as the heart rate (HR), HR variability (HRV), blood pressure (BP), BP variability (BPV), and the retinal microvasculature of healthy participants; (2) Methodology: Thirty (14 males and 16 females) healthy, non-smoking participants between 23 and 71 years old (46 ± 18 years) were included in this randomized crossover study. Each participant was tested with a placebo (using LED light) and gem lights, 24 h apart. Hemodynamic parameters were recorded during the session, and 24 h heart rate and BP levels were assessed via mobile devices. Retinal vascular responses were captured with fundus images and the subsequent analysis of retinal vessel widths. A linear model, using repeated measures ANOVA, was used to compare the responses across the sexes and to assess the effect of the MLT; (3) Results: Changes in the central retinal artery equivalent (CRAE) ( < 0.001) and central retinal vein equivalent (CRVE) ( = 0.002) parameters were observed. CRAE and CRVE decreased under MLT and increased under the placebo condition from before to after. However, the baseline values of the participants already differed significantly before the application of any therapy, and the variation in the retinal vessel diameters was already large in the baseline measurements. This suggests that the observed effect results may only reflect naturally occurring fluctuations in the microcirculation and not the effect of MLT. Furthermore, no significant effects were observed in any other investigated parameters; (4) Conclusion: Our study with healthy participants finds significant changes in retinal parameters, but the biological variation in the baseline measurements was large to begin with. This suggests that the observed effect results only reflect naturally occurring fluctuations in the microcirculation and not the effect of MLT. However, in the future, larger studies in which MLT is applied for longer periods and/or in patients with different diseases could discover the physiological impacts of this type of therapy.
（1）背景：研究报告了光疗法在各种医学病症中的有效性。我们的初步研究旨在评估玛赫西光疗法（MLT）对健康参与者的生理参数的影响，如心率（HR）、心率变异性（HRV）、血压（BP）、血压变异性（BPV）以及视网膜微血管；（2）方法：本随机交叉研究纳入了30名（14名男性和16名女性）年龄在23至71岁（46±18岁）的健康非吸烟参与者。每位参与者分别在间隔24小时的时间接受安慰剂（使用LED灯）和宝石灯测试。在测试过程中记录血流动力学参数，并通过移动设备评估24小时心率和血压水平。用眼底图像捕捉视网膜血管反应，并随后分析视网膜血管宽度。使用重复测量方差分析的线性模型来比较不同性别之间的反应，并评估MLT的效果；（3）结果：观察到视网膜中央动脉等效直径（CRAE）（<0.001）和视网膜中央静脉等效直径（CRVE）（=0.002）参数的变化。从治疗前到治疗后，CRAE和CRVE在MLT治疗下降低，在安慰剂条件下升高。然而，参与者的基线值在任何治疗应用之前就已经存在显著差异，并且在基线测量中视网膜血管直径的变化已经很大。这表明观察到的效果结果可能仅反映了微循环中自然发生的波动，而非MLT的效果。此外，在任何其他研究参数中均未观察到显著效果；（4）结论：我们对健康参与者的研究发现视网膜参数有显著变化，但基线测量中的生物学变异一开始就很大。这表明观察到的效果结果仅反映了微循环中自然发生的波动，而非MLT的效果。然而，未来进行更长时间应用MLT和/或针对不同疾病患者的更大规模研究可能会发现这种疗法的生理影响。
