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使用机器学习方法预测糖尿病的发病

Predicting the Onset of Diabetes with Machine Learning Methods.

作者信息

Chou Chun-Yang, Hsu Ding-Yang, Chou Chun-Hung

机构信息

Research Center for Healthcare Industry Innovation, National Taipei University of Nursing and Health Sciences, Taipei 112, Taiwan.

Department of Industrial Design, Ming Chi University of Technology, Taipei 243, Taiwan.

出版信息

J Pers Med. 2023 Feb 24;13(3):406. doi: 10.3390/jpm13030406.

Abstract

The number of people suffering from diabetes in Taiwan has continued to rise in recent years. According to the statistics of the International Diabetes Federation, about 537 million people worldwide (10.5% of the global population) suffer from diabetes, and it is estimated that 643 million people will develop the condition (11.3% of the total population) by 2030. If this trend continues, the number will jump to 783 million (12.2%) by 2045. At present, the number of people with diabetes in Taiwan has reached 2.18 million, with an average of one in ten people suffering from the disease. In addition, according to the Bureau of National Health Insurance in Taiwan, the prevalence rate of diabetes among adults in Taiwan has reached 5% and is increasing each year. Diabetes can cause acute and chronic complications that can be fatal. Meanwhile, chronic complications can result in a variety of disabilities or organ decline. If holistic treatments and preventions are not provided to diabetic patients, it will lead to the consumption of more medical resources and a rapid decline in the quality of life of society as a whole. In this study, based on the outpatient examination data of a Taipei Municipal medical center, 15,000 women aged between 20 and 80 were selected as the subjects. These women were patients who had gone to the medical center during 2018-2020 and 2021-2022 with or without the diagnosis of diabetes. This study investigated eight different characteristics of the subjects, including the number of pregnancies, plasma glucose level, diastolic blood pressure, sebum thickness, insulin level, body mass index, diabetes pedigree function, and age. After sorting out the complete data of the patients, this study used Microsoft Machine Learning Studio to train the models of various kinds of neural networks, and the prediction results were used to compare the predictive ability of the various parameters for diabetes. Finally, this study found that after comparing the models using two-class logistic regression as well as the two-class neural network, two-class decision jungle, or two-class boosted decision tree for prediction, the best model was the two-class boosted decision tree, as its area under the curve could reach a score of 0.991, which was better than other models.

摘要

近年来,台湾糖尿病患病人数持续上升。根据国际糖尿病联盟的统计,全球约有5.37亿人患有糖尿病(占全球人口的10.5%),预计到2030年将有6.43亿人患病(占总人口的11.3%)。如果这种趋势持续下去,到2045年这一数字将跃升至7.83亿(12.2%)。目前,台湾糖尿病患病人数已达218万,平均每十人中有一人患病。此外,据台湾地区“健保局”统计,台湾成年人糖尿病患病率已达5%,且逐年上升。糖尿病可引发急性和慢性并发症,甚至可能致命。同时,慢性并发症会导致各种残疾或器官功能衰退。如果不给糖尿病患者提供全面的治疗和预防,将导致更多医疗资源的消耗,以及整个社会生活质量的迅速下降。在本研究中,基于台北市一家医疗中心的门诊检查数据,选取了15000名年龄在20至80岁之间的女性作为研究对象。这些女性是在2018 - 2020年及2021 - 2022年期间前往该医疗中心就诊的患者,其中部分被诊断患有糖尿病,部分未被诊断患有糖尿病。本研究调查了这些研究对象的八个不同特征,包括怀孕次数、血糖水平、舒张压、皮脂厚度、胰岛素水平、体重指数、糖尿病家族史功能以及年龄。在整理完患者的完整数据后,本研究使用微软机器学习工作室对各种神经网络模型进行训练,并将预测结果用于比较各种参数对糖尿病的预测能力。最后,本研究发现,在使用二类逻辑回归以及二类神经网络、二类决策丛林或二类增强决策树进行预测的模型比较中,最佳模型是二类增强决策树,因为其曲线下面积得分可达0.991,优于其他模型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0481/10057336/89cc9740870b/jpm-13-00406-g001.jpg

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