State Key Laboratory of Advanced Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
Int J Mol Sci. 2022 May 23;23(10):5831. doi: 10.3390/ijms23105831.
Polylactic acid-glycolic acid (PLGA) has been widely used in bone tissue engineering due to its favorable biocompatibility and adjustable biodegradation. 3D printing technology can prepare scaffolds with rich structure and function, and is one of the best methods to obtain scaffolds for bone tissue repair. This review systematically summarizes the research progress of 3D-printed, PLGA-based scaffolds. The properties of the modified components of scaffolds are introduced in detail. The influence of structure and printing method change in printing process is analyzed. The advantages and disadvantages of their applications are illustrated by several examples. Finally, we briefly discuss the limitations and future development direction of current 3D-printed, PLGA-based materials for bone tissue repair.
聚乳酸-乙醇酸共聚物（PLGA）由于其良好的生物相容性和可调节的生物降解性，已被广泛应用于骨组织工程。3D 打印技术可以制备具有丰富结构和功能的支架，是获得骨组织修复支架的最佳方法之一。本综述系统地总结了 3D 打印的、基于 PLGA 的支架的研究进展。详细介绍了支架改性成分的性质。分析了打印过程中结构和打印方法变化的影响。通过几个实例说明了它们应用的优缺点。最后，我们简要讨论了当前用于骨组织修复的 3D 打印的基于 PLGA 的材料的局限性和未来发展方向。
