School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China.
School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China.
Adv Drug Deliv Rev. 2023 Jun;197:114823. doi: 10.1016/j.addr.2023.114823. Epub 2023 Apr 15.
As the global number of chronic wound patients rises, the financial burden and social pressure on patients increase daily. Stem cells have emerged as promising tissue engineering seed cells due to their enriched sources, multidirectional differentiation ability, and high proliferation rate. However, delivering them in vitro for the treatment of skin injury is still challenging. In addition, bacteria from the wound site and the environment can significantly impact wound healing. In the last decade, 3D bioprinting has dramatically enriched cell delivery systems. The produced scaffolds by this technique can be precisely localized within cells and perform antibacterial actions. In this review, we summarized the 3D bioprinting-based external delivery of stem cells and their antibiosis to improve wound healing.
随着全球慢性伤口患者数量的增加，患者的经济负担和社会压力日益增加。干细胞由于其丰富的来源、多向分化能力和高增殖率，已成为有前途的组织工程种子细胞。然而，将它们在体外用于治疗皮肤损伤仍然具有挑战性。此外，来自伤口部位和环境的细菌会对伤口愈合产生重大影响。在过去十年中，3D 生物打印极大地丰富了细胞输送系统。该技术产生的支架可以精确地定位于细胞内，并具有抗菌作用。在这篇综述中，我们总结了基于 3D 生物打印的干细胞的外部输送及其对改善伤口愈合的抗菌作用。
