肌动蛋白丝末端ATP帽模型的理论研究
Theoretical study of a model for the ATP cap at the end of an actin filament.
作者信息
Hill T L
出版信息
Biophys J. 1986 May;49(5):981-6. doi: 10.1016/S0006-3495(86)83726-2.
Abstract
The model used successfully by Pantaloni et al. to fit experimental data on steady-state actin polymerization is investigated theoretically. Many properties are deduced, as functions of the free subunit concentration. The model is simple enough so that one can examine analytically the question of whether actin shows the same dramatic phase changes associated with the GTP cap in microtubules. The answer is negative, judging from this model. However, it is possible to obtain such phase changes using the same model but with quite different, hypothetical choices of parameters. Thus, aside from its application to actin, this model is useful pedagogically to illustrate the nature of phase changes that may occur at the end of a steady-state polymer.
摘要
理论上研究了Pantaloni等人成功用于拟合稳态肌动蛋白聚合实验数据的模型。推导了许多作为游离亚基浓度函数的性质。该模型足够简单，以至于人们可以通过分析来研究肌动蛋白是否表现出与微管中GTP帽相关的相同显著相变问题。从这个模型判断，答案是否定的。然而，使用相同的模型但采用截然不同的假设参数选择，有可能获得这样的相变。因此，除了应用于肌动蛋白外，这个模型在教学上有助于说明稳态聚合物末端可能发生的相变的性质。
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本文引用的文献
1
Introductory analysis of the GTP-cap phase-change kinetics at the end of a microtubule.微管末端GTP帽相变动力学的初步分析。
Proc Natl Acad Sci U S A. 1984 Nov;81(21):6728-32. doi: 10.1073/pnas.81.21.6728.
2
Phase changes at the end of a microtubule with a GTP cap.具有GTP帽的微管末端的相变。
Proc Natl Acad Sci U S A. 1984 Sep;81(18):5772-6. doi: 10.1073/pnas.81.18.5772.
3
Interference of GTP hydrolysis in the mechanism of microtubule assembly: an experimental study.GTP水解对微管组装机制的干扰：一项实验研究。
Proc Natl Acad Sci U S A. 1984 Feb;81(3):771-5. doi: 10.1073/pnas.81.3.771.
4
Steady-state theory of the interference of GTP hydrolysis in the mechanism of microtubule assembly.GTP水解对微管组装机制干扰的稳态理论。
Proc Natl Acad Sci U S A. 1983 Dec;80(23):7234-8. doi: 10.1073/pnas.80.23.7234.
5
Dynamic instability of microtubule growth.微管生长的动态不稳定性。
Nature. 1984;312(5991):237-42. doi: 10.1038/312237a0.
6
Microtubule assembly nucleated by isolated centrosomes.由分离的中心体介导的微管组装。
Nature. 1984;312(5991):232-7. doi: 10.1038/312232a0.
7
A model for actin polymerization and the kinetic effects of ATP hydrolysis.肌动蛋白聚合模型及ATP水解的动力学效应。
Proc Natl Acad Sci U S A. 1985 Nov;82(21):7207-11. doi: 10.1073/pnas.82.21.7207.
8
Monte Carlo study of the GTP cap in a five-start helix model of a microtubule.微管五星螺旋模型中GTP帽的蒙特卡罗研究。
Proc Natl Acad Sci U S A. 1985 Feb;82(4):1131-5. doi: 10.1073/pnas.82.4.1131.
9
Phase-change kinetics for a microtubule with two free ends.具有两个自由端的微管的相变动力学
Proc Natl Acad Sci U S A. 1985 Jan;82(2):431-5. doi: 10.1073/pnas.82.2.431.
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