Division of Nephrology, Tufts Medical Center, 800 Washington Street, Box 391, Boston, MA 02111, USA.
Division of Cardiovascular Medicine, Yale School of Medicine, PO Box 208017, New Haven, CT 06520, USA.
Med Clin North Am. 2023 Jul;107(4):763-780. doi: 10.1016/j.mcna.2023.03.011. Epub 2023 Apr 15.
Cardiorenal syndrome is a term that refers to a collection of disorders involving both the heart and kidneys, encompassing multi-directional pathways between the 2 organs mediated through low arterial perfusion, venous congestion, and neurohormonal activation. The pathophysiology is complex and includes hemodynamic and neurohormonal changes, but inconsistent findings from recent studies suggest this is very heterogenous disorder. Management for ADHF remains focused on decongestion and neurohormonal blockade to overcome the intense sodium and fluid avidity of the CRS.
心脏肾综合征是一个术语，指的是涉及心脏和肾脏的一系列疾病，包括 2 个器官之间通过低动脉灌注、静脉充血和神经激素激活介导的多向途径。其病理生理学较为复杂，包括血流动力学和神经激素变化，但最近的研究结果不一致，表明这是一种非常异质性的疾病。ADHF 的治疗仍然侧重于充血和神经激素阻断，以克服 CRS 对钠和液体的强烈渴望。
