Department of Marine Biomedicine and Polar Medicine, Naval Medical Center of PLA, Naval Medical University, Shanghai 200433, China.
Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Naval Medical University, Shanghai 200433, China.
J Nat Prod. 2023 Jul 28;86(7):1754-1760. doi: 10.1021/acs.jnatprod.3c00218. Epub 2023 Jun 19.
Phyllospongianes A-E (-), five new scalarane derivatives featuring an unprecedented 6/6/6/5 tetracyclic dinorscalarane scaffold, along with the known probable biogenetic precursor, 12-deacetylscalaradial (), were isolated from the marine sponge . The structures of the isolated compounds were determined by analysis of spectroscopic data and electronic circular dichroism experiments. Compounds - are the first 6/6/6/5 tetracyclic scalarane derivatives to be reported within the scalarane family. Compounds , , and exhibited antibacterial activity against , , , , , , and with MIC values ranging from 1 to 8 μg/mL. Furthermore, compound exhibited significant cytotoxic activity on MDA-MB-231, HepG2, C4-2-ENZ, MCF-7, H460, and HT-29 cancer cell lines with IC values in the range between 0.7 and 13.2 μM.
从海洋海绵中分离得到五个新的Scalarane 衍生物（-），具有前所未有的 6/6/6/5 四环 Dinorscalarane 支架，以及已知的可能生物发生前体 12-去乙酰 Scalaradial（）。通过分析光谱数据和电子圆二色实验确定了分离化合物的结构。化合物 - 是 Scalarane 家族中首次报道的 6/6/6/5 四环 Scalarane 衍生物。化合物 、 、和 对 、 、 、 、 、 和 具有抗菌活性，MIC 值范围为 1 至 8 μg/mL。此外，化合物 对 MDA-MB-231、HepG2、C4-2-ENZ、MCF-7、H460 和 HT-29 癌细胞系具有显著的细胞毒性活性，IC 值在 0.7 至 13.2 μM 之间。
