Faculty of Dentistry, Thammasat University, Pathum Thani 12120, Thailand.
Biological Engineering Program, Faculty of Engineering, King Mongkut's University of Technology Thonburi, 126 Pracha Uthit Rd., Bang Mod, Thung Khru, Bangkok 10140, Thailand.
Int J Mol Sci. 2023 Jun 16;24(12):10231. doi: 10.3390/ijms241210231.
This study prepared low-toxicity, elemental-releasing resin-modified glass ionomer cements (RMGICs). The effect of 2-hydroxyethyl methacrylate (HEMA, 0 or 5 wt%) and Sr/F-bioactive glass nanoparticles (Sr/F-BGNPs, 5 or 10 wt%) on chemical/mechanical properties and cytotoxicity were examined. Commercial RMGIC (Vitrebond, VB) and calcium silicate cement (Theracal LC, TC) were used as comparisons. Adding HEMA and increasing Sr/F-BGNPs concentration decreased monomer conversion and enhanced elemental release but without significant effect on cytotoxicity. Rising Sr/F-BGNPs reduced the strength of the materials. The degree of monomer conversion of VB (96%) was much higher than that of the experimental RMGICs (21-51%) and TC (28%). The highest biaxial flexural strength of experimental materials (31 MPa) was significantly lower than VB (46 MPa) ( < 0.01) but higher than TC (24 MPa). The RMGICs with 5 wt% HEMA showed higher cumulative fluoride release (137 ppm) than VB (88 ppm) ( < 0.01). Unlike VB, all experimental RMGICs showed Ca, P, and Sr release. Cell viability in the presence of extracts from experimental RMGICs (89-98%) and TC (93%) was significantly higher than for VB (4%). Experimental RMGICs showed desirable physical/mechanical properties with lower toxicity than the commercial material.
本研究制备了低毒性、释原树脂改性玻璃离子水门汀（RMGIC）。考察了 2-羟乙基甲基丙烯酸酯（HEMA，0 或 5wt%）和 Sr/F 生物活性玻璃纳米粒子（Sr/F-BGNPs，5 或 10wt%）对化学/机械性能和细胞毒性的影响。商业 RMGIC（Vitrebond，VB）和硅酸钙水泥（Theracal LC，TC）用作对照。添加 HEMA 和增加 Sr/F-BGNPs 浓度会降低单体转化率并增强元素释放，但对细胞毒性没有显著影响。Sr/F-BGNPs 的增加会降低材料的强度。VB（96%）的单体转化率远高于实验性 RMGIC（21-51%）和 TC（28%）。实验材料的最大双轴弯曲强度（31 MPa）明显低于 VB（46 MPa）（<0.01），但高于 TC（24 MPa）。含 5wt%HEMA 的 RMGIC 的累积氟释放量（137 ppm）高于 VB（88 ppm）（<0.01）。与 VB 不同，所有实验性 RMGIC 均显示 Ca、P 和 Sr 的释放。实验性 RMGIC 提取物（89-98%）和 TC（93%）存在时细胞活力明显高于 VB（4%）。实验性 RMGIC 具有较低的毒性和理想的物理/机械性能，优于商业材料。
