Cheng Jianwei, Guan Na N
Motor Control Laboratory, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Clinical Center for Brain and Spinal Cord Research, Tongji University, 200092 Shanghai, China.
IBRO Neurosci Rep. 2023 Apr 3;14:441-446. doi: 10.1016/j.ibneur.2023.04.001. eCollection 2023 Jun.
Spinal cord injury (SCI) disrupts communication between the brain-derived descending commands and the intraspinal circuits, the central pattern generator (CPG), that execute movements. Dynamic changes in the interaction of the brain-spinal cord as well as in structure-function relationships play a vital role in the determination of neurological function restoration. These changes also have important clinical implications for the treatment of patients with SCI. After SCI, at both brain and spinal cord levels, detour circuits formation and neuronal plasticity have been linked to functional improvement under the condition of spontaneous recovery as well as electrical stimulation- and rehabilitative training-assisted recovery. The principles governing neural circuit remodeling and the neuronal subtypes specifically involved during the recovery from SCI are largely unknown. In the present review, we focus on how multi-level neural circuits are reconstructed after SCI. We highlight some new studies using rodent and zebrafish SCI models that describe how the intraspinal detour circuits are reconstructed and the important roles of spinal excitatory interneurons.
脊髓损伤（SCI）会破坏源自大脑的下行指令与脊髓内执行运动的中枢模式发生器（CPG）回路之间的通信。脑脊髓相互作用以及结构-功能关系的动态变化在神经功能恢复的决定中起着至关重要的作用。这些变化对SCI患者的治疗也具有重要的临床意义。SCI后，在大脑和脊髓水平，绕道回路的形成和神经元可塑性与自发恢复以及电刺激和康复训练辅助恢复条件下的功能改善有关。SCI恢复过程中神经回路重塑的调控原则以及具体涉及的神经元亚型在很大程度上尚不清楚。在本综述中，我们重点关注SCI后多级神经回路是如何重建的。我们强调了一些使用啮齿动物和斑马鱼SCI模型的新研究，这些研究描述了脊髓内绕道回路是如何重建的以及脊髓兴奋性中间神经元的重要作用。
