Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Department of Structural Biology and Center for Data Driven Discovery, St Jude Children's Research Hospital, Memphis, TN, USA.
Nat Methods. 2023 Sep;20(9):1291-1303. doi: 10.1038/s41592-023-01915-x. Epub 2023 Jul 3.
An unambiguous description of an experiment, and the subsequent biological observation, is vital for accurate data interpretation. Minimum information guidelines define the fundamental complement of data that can support an unambiguous conclusion based on experimental observations. We present the Minimum Information About Disorder Experiments (MIADE) guidelines to define the parameters required for the wider scientific community to understand the findings of an experiment studying the structural properties of intrinsically disordered regions (IDRs). MIADE guidelines provide recommendations for data producers to describe the results of their experiments at source, for curators to annotate experimental data to community resources and for database developers maintaining community resources to disseminate the data. The MIADE guidelines will improve the interpretability of experimental results for data consumers, facilitate direct data submission, simplify data curation, improve data exchange among repositories and standardize the dissemination of the key metadata on an IDR experiment by IDR data sources.
实验的清晰描述以及随后的生物学观察对于准确的数据解释至关重要。最低信息量指南定义了支持基于实验观察得出明确结论的基本数据补充。我们提出了最低信息量关于无序实验（MIADE）指南，以定义广泛科学界理解研究结构特性的实验的发现所需的参数固有无序区域（IDR）。MIADE 指南为数据生产者提供了在源头上描述实验结果的建议，为策展人向社区资源注释实验数据，以及为维护社区资源的数据库开发人员提供了建议传播数据。MIADE 指南将提高数据使用者对实验结果的可解释性，促进直接数据提交，简化数据策展，改善存储库之间的数据交换，并标准化 IDR 数据源有关 IDR 实验的关键元数据的传播。
